Results 101 to 110 of about 35,146,565 (216)

C−H Bond Activation by Iridium(III) and Iridium(IV) Oxo Complexes [PDF]

Oxidation of an iridium(III) oxo precursor enabled the structural, spectroscopic, and quantum-chemical characterization of the first well-defined iridium(IV) oxo complex.
Verplancke, H., Schneider, S., Fitterer, A., Holthausen, M.C., Delony, D., de Bruin, B., Tepaske, M.A., Neben, M.C., Tepaske, Martijn A., Holthausen, Max C., Delony, Daniel, Neben, Marc C., Fitterer, Arnd, Verplancke, Hendrik, de Bruin, Bas, Schneider, Sven   +15 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Aromatic and Benzylic C−H Bond Activation in the System Bis(dicarbonylrhodium(I))- porphyrinate−Hydrocarbon Solvent

, 2016
Aromatic and Benzylic C−H Bond Activation in the System Bis(dicarbonylrhodium(I))- porphyrinate−Hydrocarbon ...
Roman Boulatov (1273218), James P. Collman (2180702)   +1 more
core   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Iron-Catalyzed C−C Bond Formation at α-Position of Aliphatic Amines via C−H Bond Activation through 1,5-Hydrogen Transfer

, 2016
Iron-Catalyzed C−C Bond Formation at α-Position of Aliphatic Amines via C−H Bond Activation through 1,5-Hydrogen ...
Laurean Ilies (1669768), Naohiko Yoshikai (1479319), Adam Mieczkowski (2302951), Arimasa Matsumoto (1848970), Eiichi Nakamura (537079)   +4 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Solvent-Controlled Selectivity toward Exclusive C−C or C−H Bond Activation by a Cationic Metal Center

, 2016
Solvent-Controlled Selectivity toward Exclusive C−C or C−H Bond Activation by a Cationic Metal ...
Boris Rybtchinski (411894), David Milstein (1599538)   +1 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Ruthenium(II)-Catalysed sp2 C–H Bond Functionalization by C–C Bond Formation

, 2014
International audienceThe selective catalytic activation/functionalization of sp2 C–H bonds is expected to improve synthesis methods by better step number and atom economy.
Li, Bin, Dixneuf, Pierre H., Pierre H. Dixneuf, Bin Li   +3 more
core   +1 more source