Results 71 to 80 of about 28,139,687 (262)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Syntheses of Benzo[]Chromen-6-ones by Palladium Catalyzed C–H Bond Activation using Diazonium Salts

Natural Product Communications, 2017
An efficient palladium catalyzed C-H bond activation for the synthesis of benzo[ c ]chromen-6-ones using diazonium salts is described. In the presence of Pd(OAc) 2 , dppp, PivOH and K 2 CO 3 , the diazonium salt can be transformed into the product ...
Liang-Zhu Huang, Rui-Yue Ma, Lu-Nan Zhou, Zhen-Ting Du, Tao Zhang   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Cooperative α-C–H activation enabled quantitative and partial photooxidation of biomass-derived 5-hydroxymethylfurfural

Green Energy & Environment
Photocatalytic activation of C–H bonds is versatile but challenging for undergoing oriented conversion processes. Herein, a spatially site-isolated heterojunction (ZS-Vs/ZIS) of ZnIn2S4 with strong Lewis acidity (ZIS) and ZnS with S-vacancy (ZS-Vs) is ...
Jie Li, Ye Meng, Yu Wen, Yinyin He, Putla Sudarsanam, Song Yang, Hu Li   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Palladium-Catalyzed Divergent Cyclopropanation by Regioselective Solvent-Driven C(sp3)?H Bond Activation

, 2018
Reported is a tandem palladium-catalyzed Heck/regioselective C(sp3)?H activation reaction for the divergent synthesis of spiro- and fused-cyclopropanated indolines from N-methallylated 2-bromoarylamides. The regioselectivity of the C?H bond activation in
Da Sol Chung, Jiyong Park, Joo Hyun Lee, UBin Kim, Hyunjoong Kim, Mu-Hyun Baik, Sang-gi Lee, Jae Sung Lee, Won Koo Lee, Ho Ryu   +9 more
core   +1 more source

C–H bond activation of benzene and thiophene by photochemically generated rhenocene cation

International Journal of Photoenergy, 1999
A cationic rhenocene-acetonitrile adduct [Cp2Re(NCMe)](BF4)(1) reacted with an excess of benzene, thiophene, 2-methylthiophene, and pyrrole under UV irradiation to afford the C–H bond activation products [Cp2Re(H)R]BF4 (R = phenyl, 2-thienyl, 2-(5 ...
Hiroshi Ogino, Hiromi Tobita, Kouji Endo, Kiyonari Hashidzume   +3 more
doaj   +1 more source

Successive Activation of C–H and C–O Bonds of Vinyl Ethers by a Diphosphine and Hydrido-Bridged Diiridium Complex

Inorganics, 2019
The reaction of [(Cp*Ir)2(μ-dmpm)(μ-H)][OTf] (2) [Cp* = η5-C5Me5, dmpm = bis(dimethylphosphino)methane] with 2,3-dihydrofuran gives [(Cp*IrH)2(μ-dmpm){μ-(2,3-dihydrofuranyl)}][OTf] (3) in an isolated yield of 70% via the C− ...
Yoshinori Takahashi, Takuya Shimbayashi, Ken-ichi Fujita   +2 more
doaj   +1 more source

C–H Bond Activation by Iridium(III) and Iridium(IV) Oxo Complexes

, 2023
Oxidation of an iridium(III) oxo precursor enabled the structural, spectroscopic, and quantum‐chemical characterization of the first well‐defined iridium(IV) oxo complex.
Verplancke, Henrdik, Tepaske, Martijn Alexander, Fitterer, Arnd, de Bruin, Bas, Holthausen, Max C., Schneider, Sven, Delony, Daniel, Neben, Marc C.   +7 more
core   +1 more source