Results 101 to 110 of about 206,495 (234)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Enantioselective functionalization of unactivated C(sp3)–H bonds through copper-catalyzed diyne cyclization by kinetic resolution

Nature Communications
Site- and stereoselective C–H functionalization is highly challenging in the synthetic chemistry community. Although the chemistry of vinyl cations has been vigorously studied in C(sp3)–H functionalization reactions, the catalytic enantioselective C(sp3)–
Yang-Bo Chen, Li-Gao Liu, Zhe-Qi Wang, Rong Chang, Xin Lu, Bo Zhou, Long-Wu Ye   +6 more
doaj   +1 more source

Exploration of C–H and N–H-bond functionalization towards 1-(1,2-diarylindol-3-yl)tetrahydroisoquinolines

Beilstein Journal of Organic Chemistry, 2014
The synthesis of 1,2,3-trisubstituted indoles was investigated. More specifically, straightforward synthetic routes towards 1-(1,2-diarylindol-3-yl)-N-PG-THIQs (PG = protecting group, THIQ = tetrahydroisoquinoline) employing transition metal-catalyzed C ...
Michael Ghobrial, Marko D. Mihovilovic, Michael Schnürch   +2 more
doaj   +1 more source

Towards electron transport measurements in chemically modified graphene: The effect of a solvent

, 2010
Chemical functionalization of graphene modifies the local electron density of the carbon atoms and hence electron transport. Measuring these changes allows for a closer understanding of the chemical interaction and the influence of functionalization on ...
Ensslin, K., Jacobsen, A., Koehler, F. M., Stark, W. J.   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

C–H bond functionalization: recent discoveries and future directions

Beilstein Journal of Organic Chemistry, 2023
Indranil Chatterjee
doaj   +1 more source

Designing all-graphene nanojunctions by covalent functionalization

, 2011
We investigated theoretically the effect of covalent edge functionalization, with organic functional groups, on the electronic properties of graphene nanostructures and nano-junctions.
Abe S., Alice Ruini, Barone V., Bekyarova E., Burghard M., Cai J., Caldas M. J., Campos L. C., Cano-Márquez A. G., Castro Neto A. H., Caterina Cocchi, Chen W., Chen Z., Datta S. S., Deborah Prezzi, Dewar M. J. S., Dávila L. Y. A., Elisa Molinari, Farmer D. B., Farmer D. B., Geim A., Han M. Y., Hantal G., Jia X., Jiao L., Kosynkin D. V., Lair S., Li X., Loh K., Lohmann T., Lopez-Bezanilla A., Lu Y. H., Marilia J. Caldas, Nakada K., Novoselov K. S., Ponomarenko L., Prezzi D., Prezzi D., Qian H., Roothaan C. C. J., Sevinçli H., Sinitskii A., Soldano C., Son Y.-W., Sun J. T., Tachikawa H., Venkataraman L., Wang X., Wang X., Wang X., Wetmore S. D., Xia F., Yang L., Yang L., Yang X., Zhang Y.-H.   +55 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Improvement of the poly-3-hexylthiophene transistor performance using small molecule contact functionalization

, 2009
We demonstrate an approach to improve poly-3-hexylthiophene field effect transistors by modifying the gold contacts with monolayer thick pentacenequinone (PQ) or naphthalene (NL). The effective contact resistance is reduced by a factor of two and sixteen
Deibel, Carsten, Hammer, Maria S, Pflaum, Jens, Winter, Rebecca   +3 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source