Results 51 to 60 of about 576,288 (258)

Intramolecular N-H...O, intermolecular O-H...O, C-H...O and Csp³-H...πarene interactions in (2S)-2-{[(2R)-2-hydroxy-2-phenylethanoyl]amino}-4-methylpentanoic acid [PDF]

, 1999
The title compound, C₁₄H₁₉NO₄, forms a hydrogenbonded network in the solid state, consisting of one intramolecular N--H...O [N...O 2.569 (3)Å] and two intermolecular O--H...0=C [O...O 2.704(2) and 2.801 (2)Å] hydrogen bonds, with weaker C--H...O [C...O ...
Dalton, John P., Gallagher, John F., Kenny, Peter T.M., O'Donohoe, Michael   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Ethyl 3-methyl-1-oxo-4H-1,4-benzothiazine-2-carboxylate monohydrate

IUCrData, 2018
The organic molecule in the title hydrate, C12H13NO3S·H2O, is folded across the S...N vector. Chains two molecules thick extending along the a-axis direction are formed by N—H...O and O—H...O hydrogen bonds.
Yamna Baryala, Youness El Bakri, El Hassane Anouar, Abdelfettahb Zerzouf, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

4-(2-Methoxyphenyl)piperazin-1-ium 6-chloro-5-isopropyl-2,4-dioxopyrimidin-1-ide [PDF]

, 2014
In the cation of the title salt, C11H17N2O+.C7H8ClN2O2 -, the piperazine ring adopts a distorted chair conformation and contains a positively charged N atom with quaternary character.
A. El-Emam, Ali, A. Ghabbour, Hazem, A. M. Al-Omary, Fatmah, Chidan Kumar, C. S., Hoong, Kun Fun   +4 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

1,2-Diazinium hydrogen chloranilate

Acta Crystallographica Section E, 2008
In the crystal structure of the title compound, C4H5N2+·C6HCl2O4−, there are three crystallographically independent 1,2-diazinium cations and hydrogen chloranilate anions.
Kazuma Gotoh, Hiroyuki Ishida
doaj   +1 more source

HYDROGEN-BONDED SUPRAMOLECULAR ARRAY IN THE CRYSTAL STRUCTURE OF ETHYL 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLATE MONOHYDRATE [PDF]

, 2010
Indexación: Web of Science; ScieloThe crystal structure of ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate monohydrate (1), C12H10O5.H2O, was established by X-ray crystallographic analysis.
CASSELS, BRUCE K., GALDÁMEZ, ANTONIO, GARCÍA-BELTRÁN, OLIMPO   +2 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

2-[4,5-Diphenyl-2-(pyridin-4-yl)-1H-imidazol-1-yl]ethanol

IUCrData, 2017
The basic building blocks of the three-dimensional structure of the title compound, C22H19N3O, are helical chains running along the [101] direction and formed by O—H...N hydrogen bonds. C—H...O hydrogen bonds between chains generate sheets which are then
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Adel A. Marzouk, Mustafa R. Albayati   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source