Results 61 to 70 of about 576,288 (258)

8-[(1E)-1-(2-Aminophenyliminio)ethyl]-2-oxo-2H-chromen-7-olate

Acta Crystallographica Section E, 2010
The title Schiff base, C17H14N2O3, exists as an NH tautomer with the H atom of the phenol group transferred to the imine N atom. The iminium H atom is involved in a strong intramolecular N+—H...O− hydrogen bond to the phenolate O atom,
E. S. Aazam, A. F. El Husseiny, H. M. Al-Amri, Orhan Büyükgüngör   +3 more
doaj   +1 more source

4-Nitro­phenyl 2-chloro­benzoate [PDF]

, 2012
The aromatic rings in the title compound, C13H8ClNO4, enclose a dihedral angle of 39.53 (3)°. The nitro group is almost coplanar with the ring to which it is attached [dihedral angle = 4.31 (1)°].
Akhter, Toheed, Akhter, Zareen, Bolte, Michael, Iqbal, Asma, Siddiqi, Humaira Masood   +4 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

(Z)-2-(4-Nitrophenyl)-3-[4-(pyridin-4-ylmethoxy)phenyl]acrylonitrile

IUCrData, 2018
The title compound, C21H15N3O3, features an essentially planar molecule (r.m.s. deviation for all non-H atoms = 0.090 Å). An intramolecular C—H...N hydrogen bond occurs.
Qingpeng Rao, Zepeng Wang, Mingdi Yang, Zhichao Wu   +3 more
doaj   +1 more source

5-Bromo­pyrimidin-2(1H)-one [PDF]

, 2007
The geometric parameters of the title compound, C4H3BrN2O, are in the usual ranges.
Ashalatha, B. V., Bolte, Michael, Narayana, B., Sarojini, B. K., Yathirajan, H. S.   +4 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

An ab initio and AIM investigation into the hydration of 2-thioxanthine [PDF]

, 2010
Background: Hydration is a universal phenomenon in nature. The interactions between biomolecules and water of hydration play a pivotal role in molecular biology. 2-Thioxanthine (2TX), a thio-modified nucleic acid base, is of significant interest as a DNA
Xiu-Xiang Yuan, Yan-Fang Wang, Xin Wang, Wenbo Chen, John S Fossey, Ning-Bew Wong, J Fitter, NJ Kim, W Pohil, B Bagchi, AP Sokolov, YG He, JH Hendricks, A Abo-Riziq, J Schiedt, W Chin, K Schoone, R Ramaekers, M Kabeláč, M Tho Nguyen, T Van Mourik, ES Kryachko, AK Chandra, AK Chandra, RB Zhang, T Frigato, AK Chandra, OV Shishkin, AK Chandra, S Kim, SA Trygubenko, M Hanus, M Hanus, J Rejnek, JD Zhang, RHD Lyngdoh, JD Gu, GA Spiller, K Miyamoto, K Yasui, Z Wang, DJ Darensbourg, A Dafali, OH Nielsen, CE Neunert, HG Mautner, LM Twanmoh, PU Civcir, BZ Li, G Stoychev, E Kulikowska, E Speina, H Tamta, K Papakostas, AE Reed, RWF Bader, C Møller, RG Parr, C Lee, AD Becke, SF Boys, R Ditchfield, K Wolinski, U Koch, PLA Popelier, F Biegler-König, F Biegler-König, MJ Frisch, GA Jeffrey, AK Rappé, JE Del Bene, ED Becker, P Hobza, XS Li, K Hermansson, B Blicharska, V Vailikhit, JE Del Bene, X Wang   +78 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

tert-Butyl N-{3-[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]propyl}carbamate

Acta Crystallographica Section E, 2012
In the title compound, C18H21ClN2O4, the molecular sytructure is stabilized by two intramolecular N—H...O hydrogen bonds. In the crystal, molecules are linked by pairs of C—H...O hydrogen bonds, forming inversion dimers with graph-set
Jackson A. L. C. Resende, Javier A. Gomez   +1 more
doaj   +1 more source

Accurate Redeterminations of 1,1'-Dibenzoylferrocene and (4-Nitrophenyl)ferrocene [PDF]

, 1997
In the solid state, molecules of 1,1'-dibenzoylferrocene, [Fe(C₁₂H₉O)₂], (I), are linked to form infinite chains in the [100] direction via (cyclopentadienyl)C-H...O hydrogen bonds [C...O 3.354 (4) Å].
Ahmed, S. Zaka, Ferguson, George, Gallagher, John F., Glidewell, Christopher, Lewis, Arwel   +4 more
core   +1 more source