Results 71 to 80 of about 7,211,500 (239)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Brote de toxoplasmosis pulmonar en militares inmunocompetentes

Biomédica: revista del Instituto Nacional de Salud
La toxoplasmosis es una infección zoonótica frecuente con diversos mecanismos de transmisión y distribución amplia a nivel mundial. Su probabilidad de generar enfermedad está relacionada con la alteración del sistema inmunológico y la virulencia del ...
Raúl Reyes-Toledo, Laura Culma-Roa, María José López, Jairo Enrique Pérez, David Suárez-Silva   +4 more
doaj   +1 more source

Colonias penales agrícolas de los siglos XIX y XX como sustitución de la pena de prisión tradicional en Colombia

Revista Criminalidad, 2012
El artículo desarrolla el tema de la política criminal de los siglos XIX y XX y su influencia en el sistema penitenciario colombiano, concretamente en la isla prisión Gorgona y las colonias penales de Araracuara y de Oriente, dentro del panorama ...
Omar Huertas-Díaz, Lynda Layda López-Benavides, Carlos Mario Malaver-Sandoval   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Change Point Detection in Radar Reflectivity Measurements Contaminated by Speckle Noise

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
This article studies the use of airborne global navigation satellite system reflectometry techniques for remote sensing applications at regional scale.
Sarah El Hajj Chehade, Hamza Issa, Georges Stienne, Serge Reboul   +3 more
doaj   +1 more source

Representaciones sociales de normas de tránsito, agresividad, facilidad percibida en la conducción, accidentes y multas en conductores de Bogotá, D. C.

Revista Criminalidad, 2014
El objetivo principal de este trabajo fue conocer las representaciones sociales sobre normas de tránsito, y su relación con la agresividad y con la accidentalidad, y multas de tránsito autoinformadas en conductores de Bogotá.
José Ignacio Ruiz-Pérez, Iván Andrés Gómez, Ingrid Tatiana Beltrán, Dyan Andrea Lamus, Liz Jeysy Leal-Salazar   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Medición de la compensación del riesgo en el mercado de criptomonedas - Measuring risk compensation in the cryptocurrency market

Suma de Negocios
Introducción/objetivo: este estudio analiza el rendimiento ajustado al riesgo de las criptomonedas más populares en comparación con el índice S&P 500, utilizando el Alpha de Jensen para evaluar si estas superan el rendimiento ajustado por riesgo en el ...
Andrés Caicedo Carrero , Jorge Alexander Cortés Cortés, Wilmar Arnulfo Bravo Murillo, Myriam Aydee Moreno Garzón   +3 more
doaj   +1 more source