Results 271 to 280 of about 24,065 (296)
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Bioorganic & Medicinal Chemistry, 2013
Cyclic-di-GMP (c-di-GMP) is a central regulator of bacterial behavior. Various studies have implicated c-di-GMP in biofilm formation and virulence factor production in multitudes of bacteria. Hence it is expected that the disruption of c-di-GMP signaling could provide an effective means to disrupt biofilm and/or virulence factor formation in several ...
Jie, Zhou +7 more
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Cyclic-di-GMP (c-di-GMP) is a central regulator of bacterial behavior. Various studies have implicated c-di-GMP in biofilm formation and virulence factor production in multitudes of bacteria. Hence it is expected that the disruption of c-di-GMP signaling could provide an effective means to disrupt biofilm and/or virulence factor formation in several ...
Jie, Zhou +7 more
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Emerging paradigms for PilZ domain-mediated C-di-GMP signaling
Biochemical Society Transactions, 2019Abstract PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local ...
Qing Wei Cheang +3 more
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c-di-GMP-mediated regulation of virulence and biofilm formation
Current Opinion in Microbiology, 2007It is now apparent that the signaling molecule 3',5'-cyclic diguanylic acid (c-di-GMP) is a central regulator of the prokaryote biofilm lifestyle and recent evidence also links this molecule to virulence. Environmentally responsive signal transduction systems that control expression and/or activity of the enzymes (GGDEF and EAL domain containing ...
Peggy A, Cotter, Scott, Stibitz
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c-di-GMP Displays A Monovalent Metal Ion-Dependent Polymorphism
Journal of the American Chemical Society, 2004Cyclic diguanosine monophosphate (c-di-GMP) is known to be an important signaling molecule that regulates the formation of bacterial biofilms. We demonstrate here by UV, CD, and NMR that it displays a surprising polymorphism that varies with the monovalent counterion and is consistent with the formation of a G-quartet structure in K+ and a stacked ...
Zhaoying, Zhang +2 more
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Synthesis and Characterization of C8 Analogs of c-di-GMP
Nucleosides, Nucleotides and Nucleic Acids, 2011We have synthesized five analogs of c-di-GMP with different substituents at the guanine C8 position, to study their effects on the metal-dependent polymorphism we had previously demonstrated for the parent compound. Of these, only the K(+) salt of c-di-Br-GMP, 2, forms higher order complexes, predominantly two different syn octamolecular ones. Its Na(+)
Elizabeth, Veliath +3 more
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Cyclin-like function of bacterial c-di-GMP
Science Signaling, 2015The bacterial second messenger c-di-GMP controls cell cycle progression.
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[Structure and function of c-di-GMP riboswitches].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2018Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous nucleotide second messenger present in a wide variety of bacteria. It regulates many important bacterial physiological functions such as biofilm formation, motility, adhesion, virulence and extracellular polysaccharide synthesis.
Xinfeng, Li +3 more
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Regulation by c-di-GMP in Myxococcus xanthus
2020Myxococcus xanthus has a complex lifecycle that is regulated by nutrient availability. In the presence of nutrients, M. xanthus cells grow, divide, and move to assemble into colonies that feed cooperatively either saprophytically or on prey. In response to starvation, a developmental program is initiated that culminates in formation of multicellular ...
Perez-Burgos, M., Sogaard-Andersen, L.
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Bioprospecting c-di-GMP activated exopolysaccharides in bacteria
Summary The genetic and physiological diversity of bacteria are critical resources to discover new exopolysaccharides (EPS) as raw materials with biotechnological applications. However, uncovering new EPS is limited by their lack of production in laboratory cultures, as EPS are often cryptic and their biosynthesis only proceed upon unknown ...Daniel Perez-Mendoza +7 more
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