Results 301 to 310 of about 24,734 (337)

Principles of c-di-GMP signalling in bacteria

Nature Reviews Microbiology, 2009
On the stage of bacterial signal transduction and regulation, bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) has long played the part of Sleeping Beauty. c-di-GMP was first described in 1987, but only recently was it recognized that the enzymes that 'make and break' it are not only ubiquitous in the bacterial world, but are found in many
Regine Hengge
exaly   +3 more sources

c-di-GMP signaling in Pseudomonas syringae complex

Microbiological Research, 2023
The Pseudomonas syringae Complex is one of the model phytopathogenic bacteria for exploring plant-microbe interactions, causing devastating plant diseases and economic losses worldwide. The ubiquitous second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) plays an important role in the 'lifestyle switch' from single motile cells
Tingting, Wang, Canfeng, Hua, Xin, Deng
openaire   +2 more sources

Structural and mechanistic determinants of c-di-GMP signalling

Nature Reviews Microbiology, 2009
Bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) is a ubiquitous second messenger that regulates cell surface-associated traits in bacteria. Components of this regulatory network include GGDEF and EAL domain-containing proteins that determine the cellular concentrations of c-di-GMP by mediating its synthesis and degradation, respectively.
Tilman Schirmer, Urs Jenal
exaly   +4 more sources

You’ve come a long way: c-di-GMP signaling [PDF]

Current Opinion in Microbiology, 2012
Cyclic dimeric guanosine monophosphate (c-di-GMP) is a common, bacterial second messenger that regulates diverse cellular processes in bacteria. Opposing activities of diguanylate cyclases (DGCs) and phosphodiesterases (PDEs) control c-di-GMP homeostasis in the cell.
Holger Sondermann, Nicholas J Shikuma
exaly   +3 more sources

Regulation of c-di-GMP Metabolism in Biofilms

Future Microbiology, 2009
Cyclic (5 to 3 )-diguanosine monophosphate (c-di-GMP) is a small molecule that regulates the transition between the sessile and motile lifestyle, an integrative part of biofilm formation and other multicellular behavior, in many bacteria. The recognition of c-di-GMP as a novel secondary messenger soon raised the question about the specificity of the ...
Jonas K, Melefors O, Römling U
openaire   +3 more sources

Identification of c-di-GMP-Responsive Riboswitches

2017
Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) is an important signaling molecule for community behavior control, cell morphogenesis, and virulence in bacteria. In addition to protein effectors, this second messenger binds RNA molecules that act as riboswitches to control target gene expression.
Peltier, Johann, Soutourina, Olga
openaire   +3 more sources

Crystal structure of BrlR with c-di-GMP

Biochemical and Biophysical Research Communications, 2017
The transcriptional regulator BrlR is a member of the MerR family of multidrug transport activators in Pseudomonas aeruginosa. Recent study indicates that BrlR is a novel 3',5'-cyclic diguanylic acid (c-di-GMP) receptor and can be activated by c-di-GMP.
Harikiran, Raju, Rohan, Sharma
openaire   +2 more sources

Prevailing Concepts of c-di-GMP Signaling

2009
Recently, the list of ubiquitous bacterial secondary messengers which include cAMP and ppGpp has been extended by 3',5'-cyclic diguanylic acid (c-di-GMP). C-di-GMP metabolism is tuned by the tightly controlled activity of diguanylate cyclases and c-di-GMP-specific phosphodiesterases.
Ute, Römling, Roger, Simm
openaire   +2 more sources

Measuring Cyclic Diguanylate (c-di-GMP)-Specific Phosphodiesterase Activity Using the MANT-c-di-GMP Assay

2017
The second messenger, cyclic diguanylate (c-di-GMP), regulates a variety of bacterial cellular and social behaviors. A key determinant of c-di-GMP levels in cells is its degradation by c-di-GMP-specific phosphodiesterases (PDEs). Here, we describe an assay to determine c-di-GMP degradation rates in vitro using 2'-O-(N'-methylanthraniloyl)-cyclic ...
Dorit, Eli, Trevor E, Randall, Henrik, Almblad, Joe J, Harrison, Ehud, Banin   +4 more
openaire   +2 more sources

Multiple Roles of c-di-GMP Signaling in Bacterial Pathogenesis

Annual Review of Microbiology, 2019
The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and controls many key functions and mechanisms. In the case of bacterial pathogens, a wide variety of virulence lifestyle factors have been shown to be regulated by c-di-GMP.
Martina Valentini, Alain Filloux
exaly   +3 more sources