Results 341 to 350 of about 470,032 (357)

STING Activator c-di-GMP-Loaded Mesoporous Silica Nanoparticles Enhance Immunotherapy Against Breast Cancer.

ACS Applied Materials and Interfaces, 2020
Reversing the immunosuppressive tumor microenvironment (TME) is a strategic initiative to sensitize cancer immunotherapy. Emerging evidence shows that cyclic diguanylate monophosphate (c-di-GMP or cdG) can induce the stimulator of interferon genes (STING)
Yi-Ping Chen, Li Xu, Tao-Wei Tang, Cheuh-Hsuan Chen, Quan-hong Zheng, Tsang‐Pai Liu, C. Mou, Cheng-Hsun Wu, Si-Han Wu   +8 more
semanticscholar   +1 more source

Design and Synthesis of Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors.

Journal of Medicinal Chemistry, 2021
The formation of biofilms by clinical pathogens typically leads to chronic and recurring antibiotic-resistant infections. High cellular levels of cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger of bacteria, have been proven to be ...
Teng-Fei Xuan, Zi-Qiang Wang, Jun Liu, Haizhen Yu, Qianqian Lin, Wei-Min Chen, Jing Lin   +6 more
semanticscholar   +1 more source

Streptomyces teams up with c-di-GMP [PDF]

Nature Reviews Microbiology, 2014
A new study shows that a unique tetrameric form of c-di-GMP controls development in Streptomyces venezuelae by mediating dimerization of a transcription factor.
openaire   +2 more sources

Synthesis and Characterization of C8 Analogs of c-di-GMP

Nucleosides, Nucleotides and Nucleic Acids, 2011
We have synthesized five analogs of c-di-GMP with different substituents at the guanine C8 position, to study their effects on the metal-dependent polymorphism we had previously demonstrated for the parent compound. Of these, only the K(+) salt of c-di-Br-GMP, 2, forms higher order complexes, predominantly two different syn octamolecular ones. Its Na(+)
Elizabeth, Veliath, Seho, Kim, Barbara L, Gaffney, Roger A, Jones   +3 more
openaire   +2 more sources

c-di-GMP-mediated regulation of virulence and biofilm formation

Current Opinion in Microbiology, 2007
It is now apparent that the signaling molecule 3',5'-cyclic diguanylic acid (c-di-GMP) is a central regulator of the prokaryote biofilm lifestyle and recent evidence also links this molecule to virulence. Environmentally responsive signal transduction systems that control expression and/or activity of the enzymes (GGDEF and EAL domain containing ...
Scott Stibitz, Peggy A. Cotter
openaire   +3 more sources

Cyclin-like function of bacterial c-di-GMP

Science Signaling, 2015
The bacterial second messenger c-di-GMP controls cell cycle progression.
openaire   +2 more sources

Biofilm control by interfering with c-di-GMP metabolism and signaling.

Biotechnology Advances, 2022
Xiaobo Liu, B. Cao, Liang Yang, J. Gu
semanticscholar   +1 more source

c-di-GMP Signaling

2017
openaire   +2 more sources

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis

Chemical Society Reviews, 2013
Yue Zheng, Min Guo, Herman O Sintim
exaly  

Phosphodiesterase DosP increases persistence by reducing cAMP which reduces the signal indole

Biotechnology and Bioengineering, 2015
Ying Hu, Michael J Benedik, Thomas K Wood   +2 more
exaly