Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma [PDF]
Advanced ScienceThe transcription factor c‐Fos plays a key role in liver metabolism, stress responses, and carcinogenesis. Here, the role of hepatic c‐Fos in the pathophysiology of metabolic dysfunction‐associated steatotic liver disease and hepatocellular carcinoma ...
Ao Li +8 more
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Abnormal c-Fos expression in TetTag mice containing fos-EGFP [PDF]
Frontiers in Behavioral NeuroscienceMolecular and genetic techniques now allow selective tagging and manipulation of the population of neurons, often referred to as “engram cells,” that were active during a specific experience.
Jacob H. Wilmot +13 more
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Dynamics of stress-induced c-fos expression in the rat prelimbic cortex: lessons from intronic and mature RNA and protein analyses [PDF]
Neurobiology of StressDespite the extensive use of c-fos as a marker of stress-induced neuronal activation, key aspects regarding its dynamics of expression remain poorly characterized. In the present study, we assessed in the prelimbic cortex of adult male rats the immediate
Patricia Molina +6 more
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Mechanisms of c-Fos regulation of mTOR signaling via ERα/β in abnormal lipid metabolism of granulosa cells in PCOS [PDF]
Frontiers in EndocrinologyObjectiveThis study investigates the role of the c-Fos/estrogen receptors (ERs)/mTOR pathway in lipid metabolism in human follicular granulosa cells of individuals with polycystic ovary syndrome (PCOS).
Xinyi Chen +13 more
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Stress-induced c-fos expression in the medial prefrontal cortex differentially affects the main residing cell phenotypes [PDF]
HeliyonStress poses a challenge to the body's equilibrium and triggers a series of responses that enable organisms to adapt to stressful stimuli. The medial prefrontal cortex (mPFC), particularly in acute stress conditions, undergoes significant physiological ...
Adriana Aguilar-Delgadillo +4 more
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C-FOS promotes the formation of neutrophil extracellular traps and the recruitment of neutrophils in lung metastasis of triple-negative breast cancer [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Neutrophil extracellular traps (NETs) are composed of DNA chains from neutrophils and associated proteolytic enzymes, which play an important role in cancer metastasis. However, the molecular mechanism of NET-mediated lung metastasis in triple-
Shuai Yan +11 more
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NMDA receptor antagonist induced c-Fos expression in the medial entorhinal cortex during postnatal development [PDF]
Frontiers in Neural CircuitsN-methyl-D-aspartate receptor (NMDAR) antagonists, including ketamine, phencyclidine (PCP), and dizocilpine (MK-801), are an important class of drugs that can produce antidepressant, hallucinogenic, dissociative, psychotomimetic, and anesthetic effects ...
Feng Liang +5 more
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AP-1-dependent c-Fos activation by TREX1 drives M2 macrophage polarization and mitigates osteoarthritis progression. [PDF]
Cell Mol Life SciZhu S +9 more
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Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells. [PDF]
PLoS ONE, 2013 The immediate early gene c-Fos is reported to be regulated by Elk-1 and cAMP response element-binding protein (CREB), but whether nuclear factor (NF)-κB is also required for controlling c-Fos expression is unclear.
Yu-Cheng Tu +4 more
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C-Fos Digital Expression Analysis in Human PapillomavirusRelated Oral Squamous Cell Carcinoma
Asian Pacific Journal of Cancer Biology, 2021 Background: Fos Proto-Oncogene (c-Fos) represents a well analyzed gene involved in solid malignancies’ development and progression. The corresponding protein forms heterodimer with c-jun, a strong transcription factor.
Aristeidis Chrysovergis +11 more
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