Results 1 to 10 of about 19,750,598 (378)
Current Opinion on the Use of c-Fos in Neuroscience. [PDF]
NeuroSci, 2022 For years, the biochemical processes that are triggered by harmful and non-harmful stimuli at the central nervous system level have been extensively studied by the scientific community through numerous techniques and animal models.
Lara Aparicio SY +10 more
europepmc +5 more sources
The pattern of c-Fos expression and its refractory period in the brain of rats and monkeys [PDF]
Frontiers in Cellular Neuroscience, 2015 Intense activation of neurons triggers the appearance of immediate expression genes, including c-fos. This gene is related to various signal cascades involved in biochemical processes such as neuronal plasticity, cell growth and mitosis.
Vanessa N Barros +5 more
doaj +5 more sources
Immediate Early Gene c-fos in the Brain: Focus on Glial Cells
Brain Sciences, 2022 The c-fos gene was first described as a proto-oncogene responsible for the induction of bone tumors. A few decades ago, activation of the protein product c-fos was reported in the brain after seizures and other noxious stimuli.
Fernando Cruz-Mendoza +4 more
doaj +2 more sources
Involvement of c-Fos in cell proliferation, migration, and invasion in osteosarcoma cells accompanied by altered expression of Wnt2 and Fzd9. [PDF]
PLoS ONE, 2017 Osteosarcoma (OS) is an aggressive bone tumor, and proto-oncogene c-Fos is involved in this lethal disease. However, the role and molecular mechanism of c-Fos in the development and progression of OS remain enigmatic.
Qiaozhen Wang +9 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2018 The cellular oncogene c-Fos (c-Fos) is a component of activator protein 1 (AP1), a master transcriptional regulator of cells. The suppression of c-Fos signaling by siRNA treatment resulted in significant induction of TLR4, which subsequently activates ...
Huynh T. Hop +10 more
doaj +2 more sources
C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells. [PDF]
PLoS ONE, 2013 BACKGROUND: The gene encoding c-fos is an important factor in the pathogenesis of joint disease in patients with osteoarthritis. However, it is unknown whether the signal mechanism of c-fos acts in intervertebral disc (IVD) cells. We investigated whether
Katsuya Yokoyama +5 more
doaj +2 more sources
Abnormal c-Fos expression in TetTag mice containing fos-EGFP [PDF]
Frontiers in Behavioral NeuroscienceMolecular and genetic techniques now allow selective tagging and manipulation of the population of neurons, often referred to as “engram cells,” that were active during a specific experience.
Jacob H. Wilmot +13 more
doaj +2 more sources
c-Fos importance for brain development
Aging, 2015 c-Fos is an immediate early response gene involved in cell proliferation and differentiation after extracellular stimuli, whereas its deregulation has been associated to oncogenic progression.
F. N. Velazquez +2 more
semanticscholar +4 more sources
Transcription Factors Modulate c-Fos Transcriptional Bursts [PDF]
Cell Reports, 2014 Transcription is a stochastic process occurring mostly in episodic bursts. Although the local chromatin environment is known to influence the bursting behavior on long timescales, the impact of transcription factors (TFs)--especially in rapidly inducible systems--is largely unknown.
A. Senecal +7 more
semanticscholar +7 more sources
c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer [PDF]
Cell Death and DiseaseAcquired drug resistance is one of the most common limitations for the clinical response of colon cancer to 5-Fluorouracil (5-FU)-based chemotherapy. The relevant molecular mechanisms might be diversity, but still not be elucidated clearly. In this study,
Yanping Gui +8 more
doaj +2 more sources