Galanin/ Neuropeptide Y Y1 receptor interaction at the cellular and receptor level in the amygdala [PDF]
, 2013 Galanin (GAL) interacts functionally with Neuropeptide Y Y1 receptor (Y1) in the nucleus tractus solitarius and the arcuate nucleus. Since GAL and Y1 participate in mood disorders, the aim of this work was to analyze GAL/Y1 interactions in the amygdala ...
Borroto-Escuela, Dasiel +8 more
core
Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis [PDF]
, 2014 Wnt signaling plays a major role in bone homeostasis and mechanotransduction, but its role and regulatory mechanism in osteoclast development are not fully understood.
Chen, Andy +5 more
core +1 more source
Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
wiley +1 more source
Reduction of adult hippocampal neurogenesis modifies brain functional connectivity and enhances cocaine-seeking in mice [PDF]
, 2015 Recently, adult hippocampal neurogenesis has been proposed as a putative neuroplastic mechanism involved in those behavioural processes. In this work, we studied the effect of the inhibition of adult hippocampal neurogenesis using the DNA alkylating ...
Blanco, Eduardo +8 more
core
Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades [PDF]
NOD-like receptor 3 (NLRP3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of Alzheimer’s disease (AD).
Chen, Jianyan +5 more
core +1 more source
New technologies for examining neuronal ensembles in drug addiction and fear [PDF]
, 2013 Correlational data suggest that learned associations are encoded within neuronal ensembles. However, it has been difficult to prove that neuronal ensembles mediate learned behaviours because traditional pharmacological and lesion methods, and even newer ...
A Badiani +148 more
core +1 more source
Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors
Advanced Science, EarlyView.Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon +10 more
wiley +1 more source
Propofol induces MAPK/ERK cascade dependant expression of cFos and Egr-1 in rat hippocampal slices
BMC Research Notes, 2010 Background Propofol is a commonly used intravenous anesthetic agent, which produce rapid induction of and recovery from general anesthesia. Numerous clinical studies reported that propofol can potentially cause amnesia and memory loss in human subjects ...
Berdichevsky Yevgeny +5 more
doaj +1 more source
Dynamics of gene C-Fos activity in paraventricular nuclei of the hypothalamus of rats at light stress [PDF]
, 2015 Stress influence (light deprivation and stimulation) on gene c-fos state of early functional activity in subnuclei of paraventricular nucleus (PVN) of hypothalamus of rats in various periods of twenty-four hours (day and night) has been elucidated ...
Bulyk, R.Ye., Tymofi, O.V.
core
Tactile experience induces c-fos expression in rat barrel cortex [PDF]
, 2000 Understanding gene expression that is responsive to sensory stimulation is central to elucidate molecular mechanisms underlying neuronal plasticity. In this study we demonstrate two new methods of stimulating whiskers that provide major sensory input to ...
Berdel, B. +4 more
core +2 more sources