Propofol induces MAPK/ERK cascade dependant expression of cFos and Egr-1 in rat hippocampal slices
BMC Research Notes, 2010 Background Propofol is a commonly used intravenous anesthetic agent, which produce rapid induction of and recovery from general anesthesia. Numerous clinical studies reported that propofol can potentially cause amnesia and memory loss in human subjects ...
Berdichevsky Yevgeny +5 more
doaj +1 more source
Blood, 2011 MicroRNAs (miRNAs) are small, noncoding RNAs that regulate target mRNAs by binding to their 3' untranslated regions. There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a ...
I. Dunand-Sauthier +10 more
semanticscholar +1 more source
EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells
Advanced Science, EarlyView.ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li +15 more
wiley +1 more source
PCP-based mice models of schizophrenia: differential behavioral, neurochemical and cellular effects of acute and subchronic treatments [PDF]
, 2015 Rationale N-methyl-D-aspartate receptor (NMDA-R) hypofunction has been proposed to account for the pathophysiology of schizophrenia. Thus, NMDA-R blockade has been used to model schizophrenia in experimental animals.
Artigas, Francesc +2 more
core +1 more source
PLoS ONE, 2011 Background Memory impairment is a frequent complication of brain ischemia. Neurogenesis is implicated in learning and memory and is regulated by the transcription factor c-Fos.
Yi-Wei Tsai +3 more
semanticscholar +1 more source
Enhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications
Advanced Science, EarlyView.This study uses multiomics approaches to characterize bovine myogenesis in vitro, identifying media components that enhance myogenic progenitor cell differentiation in 2D and 3D models. Notably, the enhanced conditions promoted formation of unique cell populations and contractile muscle cells expressing mature myogenic markers.
Christine L. Trautmann +4 more
wiley +1 more source
Ефекти епіталону на експресію гена „надранньої відповіді” c-fos у суб’ядрах паравентрикулярного ядра гіпоталамуса за умов постійного освітлення [PDF]
, 2012 Досліджено вплив епіталону на стан гена ранньої функціональної активності c-fos у суб’ядрах паравентрикулярного ядра (ПВЯ) гіпоталамуса щурів у різні проміжки доби (вдень і вночі).
Булик Роман Євгенович
core
GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway.
Molecular Endocrinology, 2011 Despite extensive studies on GnRH regulation of the gonadotropin subunit genes, very little is known about mechanism of induction of intermediary immediate early genes, such as c-Fos, that are direct targets of GnRH signaling and that upon induction ...
Heather A. Ely +2 more
semanticscholar +1 more source
Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives
Advanced Science, EarlyView.Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu +13 more
wiley +1 more source
Stress-induced reduction of dorsal striatal D2 dopamine receptors prevents retention of a newly acquired adaptive coping strategy [PDF]
, 2017 The inability to learn an adaptive coping strategy in a novel stressful condition leads to dysfunctional stress coping, a marker of mental disturbances.
Cabib, Simona +5 more
core +1 more source