Results 131 to 140 of about 167,917 (334)

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Spaceflight modulates gene expression in the whole blood of astronauts [PDF]

, 2016
Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to disease, including infectious diseases.
Barrila, Jennifer, Crabbé, Aurélie, LeBlanc, Carly, Mehta, Satish K, Nickerson, Cheryl A, Ott, C Mark, Pierson, Duane L, Stafford, Phillip   +7 more
core   +2 more sources

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Methamphetamine withdrawal induces activation of CRF neurons in the brain stress system in parallel with an increased activity of cardiac sympathetic pathways. [PDF]

, 2018
Methamphetamine (METH) addiction is a major public health problem in some countries. There is evidence to suggest that METH use is associated with increased risk of developing cardiovascular problems.
AA Robinson, AC Sharko, Alexis Bailey, AM Stamatakis, BK Yamamoto, BL Henry, C Nuñez, CP Chu, CP Motbey, D Ciccarone, D Ongur, D Sulzer, DS Latchman, E Martinez-Laorden, E Martínez-Laoden, EM Tunbridge, EV Mymrikov, GC Wagner, GF Koob, GF Koob, GF Koob, H Ito, IN Krasnova, J Beuten, JA Garcia-Carmona, JA Garcia-Carmona, JB Dietrich, JF Cubells, JF Nash, JN Peart, Juan Antonio García-Carmona, K Wada, KD Ersche, KJ Wiechelman, LA Oliveira, LZ Yang, Maria Luisa Laorden, ME Toth, MF Olive, MJ LaVoie, MJ Nijsen, MJ Nijsen, ML Loogrip, P Georgiou, P Georgiou, P Mehlen, Panos Zanos, PE Sawchenko, Polymnia Georgiou, PR Dunkley, PY Risold, R Dettmeyer, R Gonzales, S Ammon-Treiber, S Kasch, S Kaye, SE Daniel, SE Stephans, SJ O’Dell, T Abekawa, T Li, T Rogalla, TB Kazakova, W Francesconi, WJ Panenka, WP Nobis, X Deng, Y Yu   +67 more
core   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Proliferative signaling initiated in ACTH receptors

Brazilian Journal of Medical and Biological Research, 2000
This article reviews recent results of studies aiming to elucidate modes of integrating signals initiated in ACTH receptors and FGF2 receptors, within the network system of signal transduction found in Y1 adrenocortical cells.
C.F.P. Lotfi, A.P. Lepique, F.L. Forti, T.T. Schwindt, C.B. Eichler, M.O. Santos, I.T. Rebustini, G.N.M. Hajj, L. Juliano, H.A. Armelin   +9 more
doaj   +1 more source

c‐Fos is essential for the response of the tyrosine hydroxylase gene to depolarization or phorbol ester [PDF]

, 2003
Baoyong Sun, A. William Tank
openalex   +1 more source

Paternal early life stress exerts intergenerational effects on male C57Bl/6J offspring risk-taking behaviors and predator scent-induced c-Fos expression [PDF]

, 2023
U Thivisol, Phoebe Ho, Baijia Li, Mari Trompke, Lucas B. Hoffmann, Anthony J. Hannan, Terence Y. Pang   +6 more
openalex   +1 more source

Asymmetric c-fos expression in the ventral orbital cortex is associated with impaired reversal learning in a right-sided neuropathy [PDF]

, 2014
BACKGROUND: Recently we showed that unilateral peripheral neuropathic lesions impacted differentially on rat's emotional/cognitive behavior depending on its left/right location; importantly, this observation recapitulates clinical reports.
Armando Almeida, Birrell JM, Helena Anjos-Martins, Hugo Leite-Almeida, João José Cerqueira, Mao J, Marco Rafael Guimarães, Nuno Ribeiro-Costa, Nuno Sousa, Paxinos G   +9 more
core   +1 more source

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source