Results 131 to 140 of about 19,750,598 (378)

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

New technologies for examining neuronal ensembles in drug addiction and fear [PDF]

, 2013
Correlational data suggest that learned associations are encoded within neuronal ensembles. However, it has been difficult to prove that neuronal ensembles mediate learned behaviours because traditional pharmacological and lesion methods, and even newer ...
A Badiani, A Chung, A Garner, A Vazdarjanova, A Wikler, AE Kelley, AK Ghosh, AL Barth, AL Barth, AR Garner, B Sinner, BJ Everitt, BJ Mattson, BJ Mattson, Bruce T. Hope, BT Hope, C Cifani, C Grienberger, C Luscher, Carl R. Lupica, CD Harvey, CD Schwindel, CJ Guenthner, CL Pickens, CM Alberini, CM Pennartz, CP O'Brien, CR Schuster, D Farquhar, D Guez-Barber, D Guez-Barber, Danielle H. Guez-Barber, DH Root, DJ Calu, DM Labiner, DO Hebb, DS Bredt, E Bakina, E Koya, E Koya, E Valjent, EA Kiyatkin, Eisuke Koya, ER John, Fabio C. Cruz, G Buzsaki, GE Hardingham, GE Hardingham, GJ LaHoste, GJ Quirk, GM Alexander, GM Kasof, GM Kasof, GM Kasof, GM Thomas, GV Rebec, H Crombag, H Marie, HC Pape, J O'Keefe, J Sanders, J Stewart, J Stewart, JD Bremner, JD Dougherty, JD Kreuter, JD Sweatt, Jennifer M. Bossert, JF Guzowski, JF Guzowski, JF Guzowski, JH Han, JH Han, JI Morgan, JJ Knierim, JL Neisewander, JM Bossert, JT Isaac, JW Grimm, JW Johnson, JY Chang, K Deisseroth, K Hashikawa, K Nader, KK Tayler, KS Santone, L Reijmers, L Yassin, LG Reijmers, LL Peoples, LS Lerea, M Mameli, M Peter, M Sheng, MA Nicolelis, MA Ungless, ME Wolf, MJ Thomas, MK Lobo, MK Lobo, MR Penner, MS Bowers, N Matsuo, NC Tronson, NJ Marchant, O Yizhar, P O'Donnell, PL Wood, PW Kalivas, R Paz, RJ Mullen, RJ Purgert, RL Clem, RM Carelli, RM Carelli, RM Carelli, RM Carelli, S Cohen, S Fanous, S Fanous, S Ikemoto, S Maren, S Mennerick, S Siegel, SA Josselyn, SC Rogan, SG Nair, SG Nair, SJ Martin, SJ Russo, SK Barot, SL Karsten, SR Goldberg, T Herdegen, T Kawashima, TE Brown, U Shalev, UE Ghitza, V Sgambato, VB Mountcastle, VY Cao, X Liu, Y Dong, Y Shaham, Y Shaham, Y Zhou, Y Ziv, Yavin Shaham, YH Huang   +148 more
core   +1 more source

To scratch an itch: Establishing a mouse model to determine active brain areas involved in acute histaminergic itch

IBRO Reports, 2018
Background: Strategies to efficiently control itch require a deep understanding of the underlying mechanisms. Several areas in the brain involved in itch and scratching responses have been postulated, but the central mechanisms that drive pruritic ...
Sarah Ehling, Ashley Butler, Stephanie Thi, H. Troy Ghashghaei, Wolfgang Bäumer   +4 more
doaj  

Posttranscriptional regulation of c-fos mRNA expression

Nucleic Acids Research, 1987
The transient induction of c-fos mRNA and protein suggests that regulation occurs not only by transcriptional activation but also at the level of turnover of the gene product. Here we present evidence for the rapid turnover of c-fos mRNA and some of the requirements for its specific degradation. The half life of induced mature cytoplasmic c-fos mRNA is
Rahmsdorf, H. J., Schoenthal, A., Angel, P., Litfin, M., Ruether, U., Herrlich, P.   +5 more
openaire   +4 more sources

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, EarlyView.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis [PDF]

, 2014
Wnt signaling plays a major role in bone homeostasis and mechanotransduction, but its role and regulatory mechanism in osteoclast development are not fully understood.
Chen, Andy, Hamamura, Kazunori, Nishimura, Akinobu, Sudo, Akihiro, Tanjung, Nancy, Yokota, Hiroki   +5 more
core   +1 more source

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences. [PDF]

, 1988
Morgan Sheng, Scott T. Dougan, Grant McFadden, M. E. Greenberg   +3 more
openalex   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

Advanced Science, EarlyView.
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye, Shi Li, Guofang Bi, Binghui Li, Zhai Cai, Meixian Jin, Ying Zhang, Wanren Yang, Yang Li, Shao Li, Wei Hu, Yi Gao, Mingxin Pan, Shuqin Zhou, Chao Zhang, Huichang Bi, Qing Peng   +16 more
wiley   +1 more source

Estrogen Regulation of Jun and Fos in MCF-7 Cells

, 2013
C-Fos and c-Jun are transcription factors that form the dimer Activator Protein 1 (AP-1) and bind DNA to initiate transcription. C-Fos, c-Jun are targets of the Extracellular Signal-Regulated Kinase (ERK) in multiple cell types, including MCF-7 breast ...
Geck, Renee, Magill, Jessica N, Schmitt, John M   +2 more
core  

Dynamics of gene C-Fos activity in paraventricular nuclei of the hypothalamus of rats at light stress [PDF]

, 2015
Stress influence (light deprivation and stimulation) on gene c-fos state of early functional activity in subnuclei of paraventricular nucleus (PVN) of hypothalamus of rats in various periods of twenty-four hours (day and night) has been elucidated ...
Bulyk, R.Ye., Tymofi, O.V.
core