The pattern of c-Fos expression and its refractory period in the brain of rats and monkeys [PDF]
Frontiers in Cellular Neuroscience, 2015 Intense activation of neurons triggers the appearance of immediate expression genes, including c-fos. This gene is related to various signal cascades involved in biochemical processes such as neuronal plasticity, cell growth and mitosis.
Vanessa N Barros +5 more
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Expression of c‐fos in hilar mossy cells of the dentate gyrus in vivo [PDF]
, 2013 Granule cells (GCs) of the dentate gyrus (DG) are considered to be quiescent--they rarely fire action potentials. In contrast, the other glutamatergic cell type in the DG, hilar mossy cells (MCs) often have a high level of spontaneous activity based on ...
Áine Duffy +3 more
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C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells. [PDF]
PLoS ONE, 2013 BACKGROUND: The gene encoding c-fos is an important factor in the pathogenesis of joint disease in patients with osteoarthritis. However, it is unknown whether the signal mechanism of c-fos acts in intervertebral disc (IVD) cells. We investigated whether
Katsuya Yokoyama +5 more
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N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation [PDF]
Oncogene, 2006 c-Fos dephosphorylated on tyrosine (c-Fos), a component of the activator protein-1 (AP-1) family of transcription factors, is expressed at very low levels in resting cells. However, its expression is rapidly upregulated in cells undergoing G(0) to S phase transition leading to AP-1-dependent gene transcription responses.
M M, Portal, G O, Ferrero, B L, Caputto
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Involvement of c-Fos in cell proliferation, migration, and invasion in osteosarcoma cells accompanied by altered expression of Wnt2 and Fzd9. [PDF]
PLoS ONE, 2017 Osteosarcoma (OS) is an aggressive bone tumor, and proto-oncogene c-Fos is involved in this lethal disease. However, the role and molecular mechanism of c-Fos in the development and progression of OS remain enigmatic.
Qiaozhen Wang +9 more
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Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling
Cell Reports, 2018 Summary: Training-dependent increases in c-fos have been used to identify engram cells encoding long-term memories (LTMs). However, the interaction between transcription factors required for LTM, including CREB and c-Fos, and activating kinases such as ...
Tomoyuki Miyashita +3 more
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Journal of Translational Medicine, 2021 Background Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity IgE Fc receptor (FcεRI) binding ...
Hui-Na Wang +6 more
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c‐Fos transrepression revisited [PDF]
FEBS Letters, 1997 The c‐fos proto‐oncogene was discovered by homology to transforming viral genes, leading to speculation that transforming viruses had captured a cellular gene involved in cell cycle control. Indeed overexpression of c‐Fos protein led to deregulated growth control, and c‐Fos was thought to be so critically involved in cell cycle control that ...
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KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. [PDF]
, 2016 KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that
Feng, X +7 more
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Expression of c-fos was associated with clinicopathologic characteristics and prognosis in pancreatic cancer. [PDF]
PLoS ONE, 2015 It has long been regarded that pancreatic cancer (PC) is a life-threatening malignant tumor. Thus, much attention has been paid for factors, especially relative molecules, predictive for prognosis of PC.
Jun-Chao Guo +7 more
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