Stress-induced c-fos expression in the medial prefrontal cortex differentially affects the main residing cell phenotypes [PDF]
HeliyonStress poses a challenge to the body's equilibrium and triggers a series of responses that enable organisms to adapt to stressful stimuli. The medial prefrontal cortex (mPFC), particularly in acute stress conditions, undergoes significant physiological ...
Adriana Aguilar-Delgadillo +4 more
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C-FOS promotes the formation of neutrophil extracellular traps and the recruitment of neutrophils in lung metastasis of triple-negative breast cancer [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Neutrophil extracellular traps (NETs) are composed of DNA chains from neutrophils and associated proteolytic enzymes, which play an important role in cancer metastasis. However, the molecular mechanism of NET-mediated lung metastasis in triple-
Shuai Yan +11 more
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Exercise induction at expression immediate early gene (c-Fos, ARC, EGR-1) in the hippocampus: a systematic review [PDF]
Dementia & Neuropsychologia. The immediate early gene exhibits activation markers in the nervous system consisting of ARC, EGR-1, and c-Fos and is related to synaptic plasticity, especially in the hippocampus. Immediate early gene expression is affected by physical exercise, which
Upik Rahmi +6 more
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Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells. [PDF]
PLoS ONE, 2013 The immediate early gene c-Fos is reported to be regulated by Elk-1 and cAMP response element-binding protein (CREB), but whether nuclear factor (NF)-κB is also required for controlling c-Fos expression is unclear.
Yu-Cheng Tu +4 more
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C-Fos Digital Expression Analysis in Human PapillomavirusRelated Oral Squamous Cell Carcinoma
Asian Pacific Journal of Cancer Biology, 2021 Background: Fos Proto-Oncogene (c-Fos) represents a well analyzed gene involved in solid malignancies’ development and progression. The corresponding protein forms heterodimer with c-jun, a strong transcription factor.
Aristeidis Chrysovergis +11 more
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c-Fos Phosphorylation Induced by H2O2 Prevents Proteasomal Degradation of c-Fos in Cardiomyocytes [PDF]
Journal of Biological Chemistry, 2004 Oxidants cause activation of the AP-1 transcription factor in cardiomyocytes. c-Fos, a component of the AP-1 transcription factor, is transiently induced by H2O2 and the induction is sensitive to the protein synthesis inhibitor cycloheximide. With high percentage gel electrophoresis, multiple c-Fos bands were resolved by Western blot analyses ...
Jerome Terrand +3 more
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N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation [PDF]
Oncogene, 2006 c-Fos dephosphorylated on tyrosine (c-Fos), a component of the activator protein-1 (AP-1) family of transcription factors, is expressed at very low levels in resting cells. However, its expression is rapidly upregulated in cells undergoing G(0) to S phase transition leading to AP-1-dependent gene transcription responses.
G O Ferrero +2 more
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Journal of Translational Medicine, 2021 Background Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity IgE Fc receptor (FcεRI) binding ...
Hui-Na Wang +6 more
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Expression of c-fos was associated with clinicopathologic characteristics and prognosis in pancreatic cancer. [PDF]
PLoS ONE, 2015 It has long been regarded that pancreatic cancer (PC) is a life-threatening malignant tumor. Thus, much attention has been paid for factors, especially relative molecules, predictive for prognosis of PC.
Jun-Chao Guo +7 more
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c‐Fos transrepression revisited [PDF]
FEBS Letters, 1997 The c‐fos proto‐oncogene was discovered by homology to transforming viral genes, leading to speculation that transforming viruses had captured a cellular gene involved in cell cycle control. Indeed overexpression of c‐Fos protein led to deregulated growth control, and c‐Fos was thought to be so critically involved in cell cycle control that ...
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