Results 201 to 210 of about 19,750,598 (378)

Fortification of FeS Clusters Reshapes Anaerobic CO Dehydrogenase into an Air‐Viable Enzyme Through Multilayered Sealing of O2 Tunnels

open access: yesAngewandte Chemie, EarlyView.
Fortification of FeS clusters in Ni─Fe CO dehydrogenase (Carboxydothermus hydrogenoformans) reshapes this anaerobic enzyme into an air‐viable variant through multilayered O2 tunnel sealing. The engineered enzyme retains structural integrity and catalytic efficiency in ambient air, offering a practical solution for industrial CO/CO2 bioconversion ...
Suk Min Kim   +9 more
wiley   +2 more sources

Prognostic Impact of Bone Mineral Density Reduction During Neoadjuvant Chemotherapy (NAC) in Patients Undergoing NAC Followed by Esophagectomy for Esophageal Cancer

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
The association between BMD reduction during NAC and the worse prognosis remains unknown, although NAC followed by esophagectomy is a standard treatment for advanced ESCC. This study appeared that BMD massive reduction was an independent prognostic factor on OS (HR, 3.30; 95% confidence interval [CI], 1.69–6.55) and RFS (HR, 2.08; 95% CI, 1.19–3.63 ...
Kazuhide Sato   +11 more
wiley   +1 more source

Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective N‐Functionalization of Heterocycles and Late‐Stage Modifications

open access: yesAngewandte Chemie, EarlyView.
N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina   +10 more
wiley   +2 more sources

Smart Transfemoral Prosthetic Socket with Motorized Cable‐Driven System

open access: yesAdvanced Intelligent Systems, EarlyView.
This study presents an innovative transfemoral socket featuring a motorized cable‐driven system and a sensorized liner, designed to adapt to changes in residual limb volume while monitoring interface pressures. Users can seamlessly control the socket in both open‐ and closed‐loop modes via a customized mobile application, enhancing comfort and ...
Linda Paternò   +7 more
wiley   +1 more source

R‐APEX: A Knowledge Graph–Based Platform for the Elucidation of the Toxicological Mechanisms of Ambient Particulate Matter

open access: yesAdvanced Intelligent Systems, EarlyView.
R‐APEX is a knowledge graph platform developed to investigate how air pollutants such as particularly fine particulate matter (PM2.5) affect human health. By integrating large‐scale biomedical data and using machine learning, it reveals pollutant–gene–disease associations.
Zhixing Zhu   +7 more
wiley   +1 more source

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

open access: bronze, 1990
B.J. Wagner   +3 more
openalex   +1 more source

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