KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. [PDF]
, 2016 KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that
Feng, X +7 more
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Journal of Ovarian Research, 2023 Background The current study attempted to investigate the role of transcription factor c-fos in the development of premature ovarian insufficiency (POI) as well as the underlying mechanism involving the MALAT1/miR-22-3p/STAT1 ceRNA network.
Ting Qiu +5 more
doaj +1 more source
Identification of c-Fos as a mitotic phosphoprotein: regulation of c-Fos by Aurora-A
Journal of Biomedical Science, 2007 The c-Fos has been implicated in the regulation of gene expression under a variety of stimuli. It is known that c-Fos undergoes protein phosphorylation, which may subsequently modulate diverse functions in cells. However, less is known about the role and phosphorylation status of c-Fos during mitosis.
Jiunn Chyi Wu +5 more
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c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis. [PDF]
PLoS Genetics, 2016 Drosophila melanogaster Piwi functions within the germline stem cells (GSCs) and the somatic niche to regulate GSC self-renewal and differentiation. How Piwi influences GSCs is largely unknown. We uncovered a genetic interaction between Piwi and c-Fos in
Jonathon D Klein +5 more
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Multiple mechanisms of growth hormone-regulated gene transcription [PDF]
, 2007 Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and formation of multiprotein ...
Calinescu, Anda Alexandra +8 more
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The expression and significance of proto-oncogene c-fos in viral myocarditis
Virology Journal, 2010 Background c-fos may play a role in the pathogenesis of some diseases. The expression and function of c-fos in viral myocarditis (VMC) have not yet been reported.
Goldstein Steven +5 more
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Induction of Apoptosis by c-Fos Protein [PDF]
Molecular and Cellular Biology, 1996 The role of c-Fos in apoptosis was examined in two Syrian hamster embryo cell lines (sup+I and sup-II) and a human colorectal carcinoma cell line (RKO), using the chimeric Fos-estrogen receptor fusion protein c-FosER. As previously reported, contrasting responses were observed when these two cell lines were placed under growth factor deprivation ...
D A Alcorta +8 more
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Medial prefrontal cortex neuronal activation and synaptic alterations after stress-induced reinstatement of palatable food seeking: a study using c-fos-GFP transgenic female rats [PDF]
, 2012 Relapse to maladaptive eating habits during dieting is often provoked by stress and there is evidence for a role of ovarian hormones in stress responses and feeding.
Baumann, Michael H +11 more
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Beta-galactosidase staining in the nucleus of the solitary tract of Fos-Tau-LacZ mice is unaffected by monosodium glutamate taste stimulation. [PDF]
PLoS ONE, 2014 Fos-Tau-LacZ (FTL) transgenic mice are used to visualize the anatomical connectivity of neurons that express c-Fos, an immediate early gene, in response to activation.
Jennifer M Stratford, John A Thompson
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Sympathetic-correlated c-Fos expression in the neonatal rat spinal cord in vitro
Journal of Biomedical Science, 2009 An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25°C, but it fails in SND genesis at ≤ 10°C.
Kuo Hsiao-Hui +4 more
doaj +1 more source