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c-fos antisense RNA blocks expression of c-fos gene in F9 embryonal carcinoma cells
Cell Differentiation and Development, 1988To study the function of proto-oncogene c-fos, we prepared an antisense plasmid that expresses in mammalian cells c-fos antisense RNA which is complementary to the endogenous c-fos mRNA. Upon transfection into undifferentiated F9 EC cells, the antisense plasmid directed constitutive expression of a large amount of c-fos antisense RNA.
B Z, Levi, J W, Kasik, K, Ozato
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C-Fos Is Not Essential for Apoptosis
Biochemical and Biophysical Research Communications, 1996The transcription factor AP-1, made up of dimers of Fos and Jun proto-oncogene products, is involved in distinct cellular processes, including cell proliferation, differentiation and apoptosis. In this study, we have used mice in which both copies of the c-fos gene were disrupted by targeted mutagenesis in order to analyze how the apoptotic response ...
C, Gajate +3 more
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c-fos regulates neuronal excitability and survival
Nature Genetics, 2002Excitotoxicity is a process in which glutamate or other excitatory amino acids induce neuronal cell death. Accumulating evidence suggests that excitotoxicity may contribute to human neuronal cell loss caused by acute insults and chronic degeneration in the central nervous system. The immediate early gene (IEG) c-fos encodes a transcription factor.
Jianhua, Zhang +5 more
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Behavioral assessment of c-fos mutant mice
Brain Research, 1994Induction of the proto-oncogene c-fos has been associated with a number of neural and behavioral responses to acute stimuli. Behavioral characterization of mice containing a mutant c-fos allele created via homologous recombination-based gene targeting was performed to analyze the role of this protein in baseline neurological properties as well as ...
R, Paylor +4 more
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Amygdala kindling and c-fos protein(s)☆
Experimental Neurology, 1988c-fos protein was visualized immunohistochemically in the brains of rats after partial amygdala seizures and generalized amygdala-kindled seizures and in seizure-free amygdala-kindled rats. Four hours following partial amygdala seizures there was a massive induction of c-fos protein in the ipsilateral piriform cortex, entorhinal cortex, and amygdala ...
M, Dragunow +2 more
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1986
It is now generally accepted that the normal cellular homologues of retroviral oncogenes, the proto-oncogenes, may have crucial physiological functions in the regulation of cellular proliferation. This hypothesis is strongly supported by the observation that three proto-oncogenes, c-sis, c-erbB and c-fms are part of the cellular growth factor-receptor ...
R. Müller, R. Bravo
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It is now generally accepted that the normal cellular homologues of retroviral oncogenes, the proto-oncogenes, may have crucial physiological functions in the regulation of cellular proliferation. This hypothesis is strongly supported by the observation that three proto-oncogenes, c-sis, c-erbB and c-fms are part of the cellular growth factor-receptor ...
R. Müller, R. Bravo
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IGF-I increases C-fos expression in FRTL5 rat thyroid cells by activating the C-fos promoter
Biochemical and Biophysical Research Communications, 1988We studied the effect of IGF-1 on c-fos mRNA expression in FRTL5 rat thyroid cells. IFG-1, or calf serum, transiently increased c-fos mRNA levels in quiescent FRTL5 cells, with the latter being more potent. This increase was prevented by actinomycin D.
DAMANTE, Giuseppe, Cox F, Rapoport B.
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Protooncogene c-fos as a Transcription Factor
1990Publisher Summary This chapter discusses the recent advances in the understanding of cellular gene regulation by c-fos—the cellular homolog of the transforming gene (v-fos) of the murine sarcoma viruses FBJ and FBR. The v-fos and c-fos genes are both capable of transforming fibroblasts, although the c-fos gene requires structural alterations.
R J, Distel, B M, Spiegelman
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Gene, 1998
In contrast to c-jun and junB, the junD gene is constitutively expressed in quiescent cells. The junD promoter, therefore, may provide a paradigm for promoters mostly active in growth arrested cells. We report here that the human junD promoter is repressed by serum and TPA.
I, Berger, Y, Shaul
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In contrast to c-jun and junB, the junD gene is constitutively expressed in quiescent cells. The junD promoter, therefore, may provide a paradigm for promoters mostly active in growth arrested cells. We report here that the human junD promoter is repressed by serum and TPA.
I, Berger, Y, Shaul
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Anticancer research, 1998
The Rb tumor suppressor protein is overexpressed in HeLa cell lines permanently transfected with a constitutively expressed c-fos gene. CP17-14 cell overexpression of Rb may be due to a balancing response to overexpression of the stimulatory effects of c-fos overexpression on transcription. The cis-acting retinoblastoma control element (RCE, -97 to -86
S R, Pai, R C, Bird
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The Rb tumor suppressor protein is overexpressed in HeLa cell lines permanently transfected with a constitutively expressed c-fos gene. CP17-14 cell overexpression of Rb may be due to a balancing response to overexpression of the stimulatory effects of c-fos overexpression on transcription. The cis-acting retinoblastoma control element (RCE, -97 to -86
S R, Pai, R C, Bird
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