Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: Is c-fos a coincidence detector? [PDF]
International Journal of Molecular Medicine, 2005 The effect of acute brief seizures on neocortical c-fos expression was investigated in rats injected with 5 mg/kg 4-aminopyridine. Electroencephalography in freely moving animals with implanted neocortical electrodes detected an average of 2.67 tonic-clonic convulsions within 1 h following the 4-AP treatment.
Mihály András +9 more
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Stimulus-specific combinatorial functionality of neuronal c-fos enhancers
Nature Neuroscience, 2015 The c-fos gene (also known as Fos) is induced by a broad range of stimuli and is a reliable marker for neural activity. Its induction mechanism and available reporter mouse lines are based exclusively on c-fos promoter activity.
Jae-Yeol Joo +4 more
semanticscholar +1 more source
Enhanced c-Fos expression in the central amygdala correlates with increased thigmotaxis in rats with peripheral nerve injury [PDF]
, 2015 Pain is associated with affective, cognitive and sensory dysfunction. Animal models can be used to observe ethologically relevant behaviours such as thigmotaxis, giving insight into how ongoing sensory abnormalities influence natural rodent behaviours ...
Rice, ASC
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Neural Regeneration Research, 2015 c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated
Ji Yun Ahn +11 more
doaj +1 more source
c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines [PDF]
, 2016 It is widely accepted that the c-Fos gene has a role in proliferation and differentiation of bone cells. ATP-induced c-Fos activation is relevant to bone homeostasis, because nucleotides that are present in the environment of bone cells can contribute to
A Gartland +36 more
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Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4. [PDF]
PLoS Pathogens, 2016 We investigated the mechanism of how the papillomavirus E2 transcription factor can activate promoters through activator protein (AP)1 binding sites. Using an unbiased approach with an inducible cell line expressing the viral transcription factor E2 and ...
Maria Delcuratolo +14 more
doaj +1 more source
Intracellular Mediators of c-fos Induction
Cold Spring Harbor Symposia on Quantitative Biology, 1988 Transcription of the c-fos proto-oncogene is rapidly and transiently induced in cells exposed to a remarkably wide range of external stimuli, including growth and differentiation factors, neurotransmitters, drugs, and mechanical stimuli (for review, see Curran 1988).
L. A. Berkowitz +6 more
openaire +3 more sources
Novel spinal pathways identified by neuronal c-Fos expression after urethrogenital reflex activation in female guinea pigs [PDF]
, 2015 © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Pudendal nerve-spinal pathways are involved in urethrogenital sensation, pain and sexual activity.
Gibbins, Ian Lewis +3 more
core +1 more source
Journal of Clinical Investigation, 1997 We examined the effect of ventilation strategy on lung inflammatory mediators in the presence and absence of a preexisting inflammatory stimulus. 55 Sprague-Dawley rats were randomized to either intravenous saline or lipopolysaccharide (LPS).
L. Tremblay +4 more
semanticscholar +1 more source
c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization [PDF]
, 2003 In laboratory animals, acupuncture needs to be performed on either anesthetized or, if unanesthetized, restrained subjects. Both procedures up-regulate c-Fos expression in several areas of the central nervous system, representing therefore a major ...
Canteras, N.s. +3 more
core +3 more sources