Results 51 to 60 of about 19,750,598 (378)

Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients. [PDF]

PLoS ONE, 2016
Although increased TNF-α has been considered to cause ineffective hematopoiesis in myelodysplastic syndromes (MDS), the mechanisms of TNF-α elevation are not known.
Yayoi Shikama, Meiwan Cao, Tomoyuki Ono, Xiaomin Feng, Hideyoshi Noji, Hideo Kimura, Kazuei Ogawa, Yuko Suzuki, Kazuhiko Ikeda, Yasuchika Takeishi, Junko Kimura   +10 more
doaj   +1 more source

Stress-induced c-Fos expression is differentially modulated by dexamethasone, diazepam and imipramine [PDF]

, 2005
Immobilization stress upregulates c-Fos expression in several CNS areas. Repeated stress or the use of drugs can modulate stress-induced c-Fos expression.
A Härfstrand, AB Ginsberg, AM Magariños, BEH Sumner, CHM Beck, DR Ziegler, E Bozas, E Senba, EJ Nestler, GE Duncan, GN Smagin, GR Heninger, J Casada, J Lachuer, JA Gray, JG Richards, JL Price, JP Herman, JP Herman, KJ Kovács, Luis Carlos Reis, Luiz Eugênio Mello, LW Swanson, MA Medeiros, Magda Alves de Medeiros, O Salminen, P Linkowski, R Duman, S Kollack-Walker, S Morinobu, T Imaki, T Imaki, T Imaki, T Unlap, WE Cullinan, WE Cullinan, WS Young, X Chen, X-Y Li   +38 more
core   +2 more sources

Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation [PDF]

, 2014
Background: Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous structures in the limbs and animal ...
Baba H, Belinda M Harris, Brett A Graham, David I Hughes, Melissa A Tadros, Philip S Bolton, Robert J Callister, Watson C   +7 more
core   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat [PDF]

, 2018
The retrosplenial cortex forms part of a network of cortical and subcortical structures that have particular importance for spatial learning and navigation in rodents.
Aggleton, John, Amin, Eman, Davies, Moira, Hindley, Emma, Nelson, Andrew, Powell, Anna, Vann, Seralynne   +6 more
core   +2 more sources

Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated c-Fos expression

Scientific Reports, 2022
Repetitive transcranial magnetic stimulation (rTMS) induces action potentials to induce plastic changes in the brain with increasing evidence for the therapeutic importance of brain-wide functional network effects of rTMS; however, the influence of sub ...
Jessica Moretti, Dylan J. Terstege, Eugenia Z. Poh, Jonathan R. Epp, Jennifer Rodger   +4 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Immunohistochemical C-FOS expression and autoradiography to study galnin/neuropeptide y Y1 receptor-receptor interactions in the amygdala [PDF]

, 2013
We have shown Galanin(GAL)/Neuropeptide Y Y1 receptor(Y1) interactions in the nucleus tractus solitarius and the arcuate nucleus. Since both peptides play an important role in mood disorders, the aim of this work was to study GAL/Y1 interactions in the ...
Borroto-Escuela, Dasiel, Díaz-Cabiale, Zaida, Flores, Antonio, Fuxe, Kjell, Millón, Carmelo, Narváez, José Ángel, Narváez, Manuel, Parrado-Romero, Concepcion, Puigcerver-Martinez, Araceli, Santin-Nuñez, Luis Javier   +9 more
core  

Analisis Ekspresi Protein c-Fos pada Cell Line Kanker Payudara

Majalah Kedokteran Andalas
Tujuan: Untuk menganalisis ekspresi protein c-Fos pada cell line kanker payudara. Metode: Penelitian ini merupakan penelitian eksperimental murni menggunakan metode imunositofluoresens untuk melihat jumlah intensitas ekspresi protein c-Fos dengan sampel ...
Aisyah Elliyanti
doaj   +1 more source

Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease. [PDF]

PLoS ONE, 2014
We previously demonstrated that APP epigenetically regulates Egr1 expression both in cultured neurons and in vivo. Since Egr1 is an immediate early gene involved in memory formation, we wondered whether other early genes involved in memory were regulated
Aurélie Hendrickx, Nathalie Pierrot, Bernadette Tasiaux, Olivier Schakman, Pascal Kienlen-Campard, Charles De Smet, Jean-Noël Octave   +6 more
doaj   +1 more source