Results 61 to 70 of about 19,750,598 (378)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

ΔFosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer\u27s Disease. [PDF]

, 2017
Alzheimer\u27s disease (AD) is characterized by cognitive decline and 5- to 10-fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear.
Aschmies, Suzan, Ashok, Annie, Chin, Jeannie, Corbett, Brian F, Fu, Chia-Hsuan, Hazra, Anupam, Iascone, Daniel M, Nestler, Eric J, Petrof, Iraklis, Pyfer, Mark S, Stephens, Gabriel S, Tosi, Umberto, You, Jason C, Zhang, Xiaohong, Zhao, Lijuan   +14 more
core   +1 more source

Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected [PDF]

, 2004
Polycystin-1, the polycystic kidney disease 1 gene product, has been implicated in several signaling complexes that are known to regulate essential cellular functions. We investigated the role of polycystin-1 in Wnt signaling and activator protein-1 (
Arnould, Bhunia, Duyndam, Giles, Grotewold, Huan, Kim, Kimberling, Kugoh, Loghman-Adham, Löhning, Morin, Moser, Muto, Newby, Ouwens, Parnell, Peters, Pritchard, Rivat, Rodova, Saadi-Kheddouci, Scheffers, Shaulian, Smits, Sorenson, Spaargaren, Streets, Sutters, Trudel, Upadhya, van Adelsberg, van Dam, van Dam, van Dam, van Dam, van de Wetering, van de Wetering   +37 more
core   +3 more sources

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Inhibitory Effects of Valproate on Impairment of Y-maze Alternation Behavior Induced by Repeated Electroconvulsive Seizures and c-Fos Protein Levels in Rat Brains [PDF]

, 2011
We previously showed that inhibition of repeated electroconvulsive shock (ECS)-induced seizures through 7-day administration of anti-epileptic drugs suppressed the impairment of spontaneous alternation behavior in the Y-maze test in rats.
Araki, Hiroaki, Hidaka, Noriaki, Li, Bingjin, Suemaru, Katsuya, Takechi, Kenshi   +4 more
core   +1 more source

Stabilized Intermediate Phase Via Pseudo‐Halide Anions Toward Highly Efficient and Light‐Soaking Stable Perovskite Solar Cells

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
The formate pseudo‐halide anion is strategically introduced at the buried interface to stabilize the intermediate phases formed during perovskite crystallization. The controlled crystallization enhances crystallinity and alleviates tensile strain, eliminating residual PbI2 near the buried interface.
Jongdeuk Seo, Yun Seop Shin, Dong Gyu Lee, Jaehwi Lee, Jina Roe, Jung Geon Son, Woojin Lee, Yeonjeong Lee, Dongmin Lee, Ji Won Song, Tae Kyung Lee, Dong Suk Kim, Jin Young Kim   +12 more
wiley   +1 more source

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP [PDF]

, 1988
Transcription of the c-fos proto-oncogene is rapidly induced by serum growth factors. A short c-fos DNA element, the serum response element (SRE), is required for this response to serum.
Gilman, M. Z.
core   +1 more source

Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling

Cell Reports, 2018
Summary: Training-dependent increases in c-fos have been used to identify engram cells encoding long-term memories (LTMs). However, the interaction between transcription factors required for LTM, including CREB and c-Fos, and activating kinases such as ...
Tomoyuki Miyashita, Emi Kikuchi, Junjiro Horiuchi, Minoru Saitoe   +3 more
doaj  

Expressão dos protooncogenes c-fos, c-myc e c-jun em miométrio normal e mioma humanos Expression of the protooncogenes c-fos, c-myc and c-jun in human normal miometrium and leiomyoma

Revista Brasileira de Ginecologia e Obstetrícia, 2006
OBJETIVO: Comparar a expressão gênica (mRNA) e protéica dos protooncogenes c-fos, c-myc e c-jun em miométrio normal e mioma humanos. MÉTODOS: Foi realizado um estudo do tipo caso-controle.
Ana Luiza Ferrari, Maria Flávia Marques Robeiro, Mateus Reche, Ilma S. Brum, Maria Beatriz Kohek, Helena von Eye Corleta, Edison Capp   +6 more
doaj   +1 more source

Glutamatergic Activation of Neuronostatin Neurons in the Periventricular Nucleus of the Hypothalamus

Brain Sciences, 2020
Neuronostatin, a newly identified anorexigenic peptide, is present in the central nervous system. We tested the hypothesis that neuronostatin neurons are activated by feeding as a peripheral factor and that the glutamatergic system has regulatory ...
Sema Serter Kocoglu, Duygu Gok Yurtseven, Cihan Cakir, Zehra Minbay, Ozhan Eyigor   +4 more
doaj   +1 more source