Results 171 to 180 of about 3,879,991 (283)

Versatile Butenolide Syntheses via a Structure-Oriented C-H Activation Reaction. [PDF]

J Am Chem Soc
Lin YK, Kim D, Ouyang Y, Yu JQ.
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A green approach to 2-arylquinolines <i>via</i> palladium-catalysed C-H activation. [PDF]

RSC Adv
Viduedo N, Pirvu L, Alves Â, Santos F, Marques MMB.   +4 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

First-principles calculations steered multi-task transformer model to screen dual-atom catalysts for C-H activation. [PDF]

iScience
Wang B, Xu W, Sun X, Ji Q, Shang L, Zhao Z, Li B.   +6 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

A brief review on the palladium-catalyzed C-H activation reactions of 2-phenylpyridines. [PDF]

RSC Adv
Joy J, Demina TD, Durgi AK, Vijayan A.
europepmc   +1 more source

Selective C-H Activation of Unprotected Allylamines by Control of Catalyst Speciation. [PDF]

Chem Catal, 2023
Landge VG, Mishra A, Thotamune W, Bonds AL, Alahakoon I, Karunarathne A, Young MC.   +6 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Construction of 1,2,3-Triazole-Embedded Polyheterocyclic Compounds via CuAAC and C-H Activation Strategies. [PDF]

Molecules
Iazzetti A, Allevi D, Fabrizi G, Gazzilli Y, Goggiamani A, Marrone F, Stipa F, Ullah K, Zoppoli R.   +8 more
europepmc   +1 more source