Results 181 to 190 of about 29,655,632 (304)

Iron tris-mesityl: a homoleptic iron(ii) ferrate species for directed C-H activation. [PDF]

Chem Sci
Radović A, Healy MC, Datta A, Das D, Cai L, Diaz S, Gogoi AR, Wolford NJ, Carpenter SH, Brenessel WW, McCamant D, Gutierrez O, Neidig ML.   +12 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Diversity-Oriented C-H Activation Reactions of the Naphthalene Scaffold. [PDF]

J Am Chem Soc
Fan Z, Hoque ME, Wu K, Palkowitz MD, Velaparthi U, Gillman KW, Qiao JX, Yu JQ.   +7 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Correction: Iron tris-mesityl: a homoleptic iron(ii) ferrate species for directed C-H activation. [PDF]

Chem Sci
Radović A, Healy MC, Datta A, Das D, Cai L, Diaz S, Gogoi AR, Wolford NJ, Carpenter SH, Brenessel WW, McCamant D, Gutierrez O, Neidig ML.   +12 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Enantioselective C-H Activation for the Construction of Chiral Tertiary Fluorides via Migrative Carbofluorination. [PDF]

J Am Chem Soc
Zhang ZY, Ouyang Y, Zhang T, Yu JQ.
europepmc   +1 more source

Palladium and norbornene catalysis for selective aromatic funcionalization via C-H activation

, 2014
CATELLANI, Marta, DELLA CA', Nicola, MOTTI, Elena   +2 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Time-Resolved Resonant Inelastic X-ray Scattering Reveals How Orbital Symmetry Alignment Enables C-H Activation. [PDF]

J Am Chem Soc
Dederichs T, Banerjee A, Kabanova V, Stefanuik R, Freibert A, Beale EV, Dworkowski F, Castillo RG, Johnson PJM, Cirelli C, Huse N, Bacellar C, Jay RM, Wernet P.   +13 more
europepmc   +1 more source