Results 131 to 140 of about 23,038 (267)

Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines

Molecules
Efficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed.
Enshen Zhang, Mei Sun, Lvlv Gao
doaj   +1 more source

Energetics of C–H bond activation of functionalized hydrocarbons. II. C–H and C–CN bond activation of acetonitrile and benzonitrile

, 2013
Thesis (Ph. D.)--University of Rochester. Dept. of Chemistry, 2011.Several transition-metal systems have been used to establish correlations between metal-carbon and carbon-hydrogen bonds. In the following studies, the [Tp’RhL] fragment where Tp’ = tris(
Jones, William D., Evans, Meagan Elizabeth (1981 - )   +1 more
core  

Activation of H-H, C-H, C-C and C-Cl bonds by Pd and PdCl-. Understanding anion assistance in C-X bond activation

, 2005
To understand the mechanism of anion assistance in palladium-catalyzed H-H, C-H, C-C and C-Cl bond activation, several mechanistic pathways for oxidative addition of Pd and ...
Jong, G.T. de, Bickelhaupt, F.M., de Jong, G.T., Diefenbach, A.   +3 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Synthesizing active and durable cubic ceria catalysts (<6 nm) for fast dehydrogenation of bio-polyols to carboxylic acids coproducing green H2

Green Energy & Environment
Dehydrogenation is considered as one of the most important industrial applications for renewable energy. Cubic ceria-based catalysts are known to display promising dehydrogenation performances in this area.
Mengyuan Liu, Puhua Sun, Guangyu Zhang, Xin Jin, Chaohe Yang, Honghong Shan   +5 more
doaj   +1 more source

sp2 C-H bond activation in water and catalytic cross-coupling reactions.

, 2013
International audienceThe metal-catalysed successive activation and functionalisation of sp(2) C-H bonds is the at heart of synthetic innovations for the development of C-C bond cross-coupling processes.
Li, Bin, Dixneuf, Pierre, H.
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

o-Halogenation and -Alkoxylation of Phenylglycine Derivatives by Pd-Mediated C-H Functionalization: Scope and Limitations

Molecules
Orthopalladated derivatives from substituted phenylglycines [Pd(μ-Cl)(C6H3R1C(R2)(R3)N(R4)2]2 (1) react with halogenating reagents (PhICl2, Br2, I2) (2) to give the corresponding o-halogenated amino acids C6H3(X)R1C(R2)(R3)N(R4)2 (3).
Eduardo Laga, Sonia Nieto, Carlos Cativiela, Esteban P. Urriolabeitia   +3 more
doaj   +1 more source

The thiolation of pentafluorobenzene with disulfides by C–H, C–F bond activation and C–S bond formation

, 2018
A metal-free thiolation reaction between pentafluorobenzene and disulfides by C–H, C–F bond activation and C–S bond formation is reported.
Zijian Liu, Nianfa Yang, Kunbing Ouyang
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source