Results 121 to 130 of about 31,613,878 (290)

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Activation of c-jun N-terminal kinase in A549 lung carcinoma cells by sodium dichorate: Role of dissociation of apoptosis signal regulating kinase-1 from 1β physiological inhibitor thioredoxin

, 2004
Changes in the components of the Jun N-terminal kinase (JNK) signalling pathway were investigated in human A549 lung carcinoma cells treated with sodium dichromate.
Chipman, James, Lewis, Nicholas, Lee, Amanda, Hodges, Nikolas, Smart, Oliver   +4 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Erbb4 (Jm-B/Cyt-1)-Induced Expression and Phosphorylation of C-Jun Is Abrogated by Human Papillomavirus Type 16 E5 Protein

, 2008
Human papillomavirus type 16 E5 (HPV-16 E5) is a highly hydrophobic membrane protein with weak-transforming activity , which is associated with ErbB4 receptor in HPV-16-infected cervical lesions.
Chen, S-L; Lin, S-T; Tsai, T-C; Hsiao, W-C; Tsao, Y-P, 陳小梨;蔡宗杰;曹友平   +1 more
core  

C-Jun N-terminal kinase (JNK) cooperates with Gsk3β to regulate Dishevelled-mediated microtubule stability-3

, 2011
Copyright information:Taken from "c-Jun N-terminal kinase (JNK) cooperates with Gsk3β to regulate Dishevelled-mediated microtubule stability"http://www.biomedcentral.com/1471-2121/8/27BMC Cell Biology 2007;8():27-27.Published online 3 Jul 2007PMCID ...
Lorenza Ciani (70164), Patricia C Salinas (70165)   +1 more
core   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

c-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion

, 2009
The c-Jun N-terminal kinase (JNK) pathway is involved in cell stress and apoptosis. We tested the hypothesis that this pathway plays a role in traumatic brain injury (TBI) by assessing JNK activation in human brain tissues and in brains of mice subjected
A. Colombo, F. Ortolano, E. R. Zanier, L. Longhi, M. G. De Simoni, A. Sclip, T. Borsello, N. Stocchetti, C. Perego   +8 more
core   +1 more source

Neuroprotective effects of quercetin in animal models of neurodegenerative diseases: A systematic review and meta‐analysis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuronal loss driven by oxidative stress and inflammation. Quercetin, a dietary flavonoid with established antioxidant and anti‐inflammatory properties, has emerged as a potential neuroprotective agent.
In Ho Cho, Hendra Mahakam Putra, Cheol Woon Jung, Gyu Hwan Hyun, Hwan‐Hee Jang, In Guk Hwang, Sung Won Kwon   +6 more
wiley   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

, 2003
Neuronal death in cerebral ischemia is largely due to excitotoxic mechanisms, which are known to activate the c-Jun N-terminal kinase (JNK) pathway. We have evaluated the neuroprotective power of a cell-penetrating, protease-resistant peptide that blocks
A. Vercelli, Clarke, P.G.H., Alessandro Vercelli, Repici, M., P. G. . H. Clarkel, Bogousslavsky, J., Tiziana Borsello, C. Bonny, J. Bogousslavsky, Bonny, C., Lorenz Hirt, Christophe Bonny, D. F. Schorderet, T. Borsellol, Daniel F Schorderet, M. Repici, Vercelli, A., Borsello, T., Mariaelena Repici, Julien Bogousslavsky, Hirt, L., L. Hirt, Peter G H Clarke, Schorderet, D.F., Borsello T, Bonny C, Hirt L, Repici M, Bogousslavsky J, Clarke PG, Vercelli A, Schorderet DF   +31 more
core   +1 more source