Results 81 to 90 of about 31,613,878 (290)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Interleukin-4 synergizes with Raf-1 to promote long-term proliferation and activation of c-jun N-terminal kinase

, 1999
This report shows that interleukin-4 (IL-4), which plays a key role in regulating immune responses, fails to support cellular growth. We investigated whether this failure of IL-4 to promote growth was because of its unique inability to activate the Ras ...
Bessette, Darrell C., Megan K. Levings, John W. Schrader, Levings, Megan K., Schrader, John W., Darrell C. Bessette   +5 more
core   +1 more source

Nuciferine Suppresses Inflammatory Hepatocarcinogenesis by Targeting cPLA2‐Dependent Arachidonic Acid Metabolism

Advanced Science, EarlyView.
Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun, Xinyan Wu, Shuwei Luo, Yilang Liu, Jie Liu, Jun Lu, Weimin Wang, Xiao Feng, Tuo Zhang, Dipak Panigrahy, Jianjun Deng, Xiaojun Liao, Haixia Yang   +12 more
wiley   +1 more source

Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense. [PDF]

PLoS ONE, 2012
The c-Jun N-terminal kinase (JNK) - 1 pathway has been implicated in the cellular response to stress in many tissues and models. JNK1 is known to play a role in a variety of signaling cascades, including those involved in lung disease pathogenesis ...
Jos Van der Velden, Yvonne M W Janssen-Heininger, Sivanarayna Mandalapu, Erich V Scheller, Jay K Kolls, John F Alcorn   +5 more
doaj   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Measuring the Constitutive Activation of c-Jun N-terminal Kinase Isoforms [PDF]

, 2010
The c-Jun N-terminal kinases (JNK) are important regulators of cell growth, proliferation, and apoptosis. JNKs are typically activated by a sequence of events that include phosphorylation of its T-P-Y motif by an upstream kinase, followed by homodimerization and translocation to the nucleus. Constitutive activation of JNK has been found in a variety of
Ryan T, Nitta, Shawn S, Badal, Albert J, Wong   +2 more
openaire   +2 more sources

FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy

Scientific Reports, 2017
FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated.
Enshuang Guo, Renlong Li, Jiankun Yang, Jun Zhang, Anyi Li, Yan Yang, Shenpei Liu, Anding Liu, Xiaojing Jiang   +8 more
doaj   +1 more source

Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons

Marine Drugs, 2015
The frequent occurrence of Moorea producens (formerly Lyngbya majuscula) blooms has been associated with adverse effects on human health. Hoiamide A is a structurally unique cyclic depsipeptide isolated from an assemblage of the marine cyanobacteria M ...
Zhengyu Cao, Xichun Li, Xiaohan Zou, Michael Greenwood, William H. Gerwick, Thomas F. Murray   +5 more
doaj   +1 more source

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.

PLoS Genetics, 2021
Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function.
Abigail O Smith, Julie A Jonassen, Kenley M Preval, Roger J Davis, Gregory J Pazour   +4 more
doaj   +1 more source

A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria

, 2002
We have identified a novel c-Jun N-terminal kinase (JNK)interacting protein, Sab, by yeast two-hybrid screening. Sab binds to and serves as a substrate for JNK in vitro, and was previously found to interact with the Src homology 3 (SH3) domain of Bruton ...
Tsukada, S., Wiltshire, C., Gillespie, D.A.F., Matsushita, M., May, G.H.W.   +4 more
core   +1 more source