Results 181 to 190 of about 81,067 (257)

Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis. [PDF]

Nat Immunol
Alvarez-Martinez M, Cox LS, Pearson CF, Branchett WJ, Chakravarty P, Wu X, Slawinski H, Al-Dibouni A, Samelis VA, Gabryšová L, Priestnall SL, Suárez-Bonnet A, Mikolajczak A, Briscoe J, Powrie F, O'Garra A.   +15 more
europepmc   +1 more source

Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf. [PDF]

Cell Death Dis, 2020
Xu Y, Sun T, Zeng K, Xu M, Chen J, Xu X, Zhang Z, Cao B, Tang X, Wu D, Kong Y, Zeng Y, Mao X.   +12 more
europepmc   +1 more source

The Genetic Link Between Primary Immune Thrombocytopenia and Depression/Anxiety Disorders: A Two‐Sample Mendelian Randomization Study

Journal of Clinical Laboratory Analysis, EarlyView.
A two‐sample Mendelian randomization study revealed a positive genetic association between primary immune thrombocytopenia (ITP) and major depressive disorder (MDD), but not with anxiety. Results remained consistent across sensitivity and multivariable analyses, indicating that ITP may causally increase susceptibility to depression.
Le Jiang, Ya‐jing Zhao, Shou‐qing Han, Zhen‐yu Yan, Xin‐guang Liu   +4 more
wiley   +1 more source

Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf. [PDF]

ACS Pharmacol Transl Sci
Li H, Zhu X, Sun Z, Wang Q, Song S, Xu Y, He G, Mao X.   +7 more
europepmc   +1 more source

Unpacking early risks for peer victimization: A network analysis of early temperament and polygenic risk scores

JCPP Advances, EarlyView.
Abstract Background Children who show difficult temperament are at risk of peer victimisation, which in turn associates with numerous negative outcomes later in life. We used network analysis to examine whether specific aspects of difficult temperament contributed to these associations, and whether the links were moderated by variations in genetic ...
Tom C.‐H. Wu, Deniz Konac, Liliana Garcia‐Mondragon, Alex F. Martin, Barbara Maughan, Ted Barker   +5 more
wiley   +1 more source

Analyzing c-Maf Functions in Mice and Searching for a Possible c-Maf Inhibitor as a Therapeutic Agent for Diabetes and Nephropathy.

Analyzing c-Maf Functions in Mice and Searching for a Possible c-Maf Inhibitor as a Therapeutic Agent for Diabetes and Nephropathy.
2023
openaire   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

Genome‐wide association study of periodontitis severity and progression

Journal of Periodontology, EarlyView.
Abstract Background To add to the knowledge base of periodontal genomics, we carried out a genome‐wide association study (GWAS) of periodontitis severity and progression among 416 mixed‐ethnicity adult participants of a periodontitis clinical study. Methods Participants were 168 adults (mean age = 50 years, 46% males) with severe periodontitis and 248 ...
Flavia Teles, Ganesh Chandrasekaran, Lynn Martin, Poojan Shrestha, Kevin Moss, Michele Patel, Michael J. Kallan, Camila Furquim, Andrew J. Cucchiara, James D. Beck, Kari E. North, Joseph Glessner, Kimon Divaris   +12 more
wiley   +1 more source

Association Between Body Mass Index and Depression/Anxiety in an East Asian Population: A Mendelian Randomization Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Obesity and psychiatric disorders are the leading causes of global morbidity. Epidemiological studies suggest a bidirectional link between higher body mass index (BMI) and mental health outcomes, but the direction of causality remains uncertain due to confounding and reverse causation. We performed a Mendelian randomization (MR) analysis using
Perl Han Lee, Szu‐Chia Chen, Chien‐Hung Lee, Jiun‐Hung Geng, Chih‐Hung Ko   +4 more
wiley   +1 more source

c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program. [PDF]

J Exp Med, 2020
Parker ME, Barrera A, Wheaton JD, Zuberbuehler MK, Allan DSJ, Carlyle JR, Reddy TE, Ciofani M.   +7 more
europepmc   +1 more source