Results 201 to 210 of about 81,330 (242)

Genetic Evolution in BRCA1‐Associated Breast Cancer Reveals Early Driver Mutations Shaping Tumor Features and Prognosis

Cancer Science, EarlyView.
Multi‐region sequencing of 57 BRCA1‐associated breast cancers identified TP53 as the dominant initial driver, defining a triple‐negative subgroup with biallelic BRCA1 loss and elevated genomic instability. TP53 truncating mutations were enriched in BRCA1 carriers and linked to reduced HRD, EMT activation, and a trend toward worse survival.
Li Hu, Zhongwu Li, Qiting Wan, Xingyu Liao, Yaxin Zhang, Qian Liu, Xinyun Ding, Hua Meng, Yifan Wu, Jie Sun, Juan Zhang, Lu Yao, Ye Xu, Yuntao Xie   +13 more
wiley   +1 more source

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Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver

Biochemical and Biophysical Research Communications, 2004
Maf is a family of oncogenes which encodes a nuclear bZip transcription factor protein and has been originally identified from the avian oncogenic retrovirus, AS42. Maf genes have been reported to have critical roles in embryological development and cellular differentiation.
Masaharu Sakai, Junkô Imaki, Hidetaka Onodera   +2 more
exaly   +3 more sources

Differential expression patterns of MafB and c-Maf in macrophages in vivo and in vitro

Biochemical and Biophysical Research Communications, 2016
The large Maf transcription factors c-Maf and MafB are expressed in macrophage-lineage hematopoietic cells, but the expression patterns of MafB and c-Maf in macrophage subtypes and tissue-resident macrophages have not been fully analyzed. First, we analyzed MafB and c-Maf protein expression in tissue-resident macrophages.
Michito Hamada, Satoru Takahashi, Hyojung Jeon   +2 more
exaly   +3 more sources

Transcription factor c-Maf-targeted cancer immunotherapy

Trends in Cancer, 2023
In innate immune cells, the transcription factor cellular musculoaponeurotic fibrosarcoma (c-Maf) influences cell fate and function through molecular and metabolic programming, thereby influencing immune homeostasis and antitumor immunity. We discuss recent c-Maf landmark discoveries with a focus on the immunosuppressive tumor microenvironment (TME ...
Yunke Wang, Fuming Qiu, Jun Yan
openaire   +2 more sources

c-Maf: The magic wand that turns on LSEC fate

Cell Stem Cell, 2022
In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs, and its overexpression specializes generic HUVECs into functional induced-LSECs, potentiating regenerative
Anna R, Smith, Valerie, Gouon-Evans
openaire   +2 more sources

Correlation between the expression level of c-maf and glutathione peroxidase-3 in c-maf −/− mice kidney and c-maf overexpressed renal tubular cells

Biochemical and Biophysical Research Communications, 2006
Large mafs are transcriptional factors and members of the basic leucine zipper (b-Zip) superfamily. Since we previously identified expression of c-maf in mouse kidney, we presently investigated the mRNA expression profile in the kidney of c-maf gene knockout mice by using DNA microarray, and plasma glutathione peroxidase-3 (GPx3) was predominantly ...
S, Shirota, T, Yoshida, M, Sakai, J I, Kim, H, Sugiura, T, Oishi, K, Nitta, K, Tsuchiya   +7 more
openaire   +2 more sources

A Chemical Biology Screen Identifies Glucocorticoids as Inhibitors of C-Maf and C-Maf-Dependent Transactivation of Cyclin D2.

Blood, 2006
Abstract The oncogene c-maf is frequently over-expressed in multiple myeloma cell lines and patient samples and contributes to increased cellular proliferation in part by inducing cyclin D2 expression. Therefore, small molecules that inhibit c-maf and its targets could be useful chemical probes to better understand the role and ...
MAO X., STEWART A. K., HURREN R., DATTI, Alessandro, SHI C. X., ZHU Y. X., LEE K., TIEDEMANN R., EBERHARD Y., COREY S. J., WRANA J., SCHIMMER A. D.   +11 more
openaire   +2 more sources

c-Maf rules the island

Blood, 2011
In this issue of Blood , Kusakabe et al make a compelling case that the transcription factor c-Maf is critical for erythroblastic island formation and fetal erythropoiesis. 1 The cell adhesion molecule VCAM-1 is a potential mediator of c-Maf activity.
openaire   +2 more sources

Variable Effects of Transgenic c-Maf on Autoimmune Diabetes

Diabetes, 2001
Autoimmune diabetes is associated with T helper 1 polarization, but protection from disease can be provided by the application of T helper 2 (Th2) cytokines. To test whether genetic manipulation of T-cells can provide protective Th2 responses, we developed transgenic mice in which T-cells express the interleukin-4-specific transcription factor c-Maf ...
M E, Pauza, A, Nguyen, T, Wolfe, I C, Ho, L H, Glimcher, M, von Herrath, D, Lo   +6 more
openaire   +2 more sources

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma

Blood, 2021
Abstract The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM), but how to achieve it is still elusive. In the present study, we found the Otub1/c-Maf axis could be a potential target.
Yujia Xu, Min Xu, Jiefei Tong, Xiaowen Tang, Jinhao Chen, Xuehan Chen, Zubin Zhang, Biyin Cao, A. Keith Stewart, Michael F. Moran, Depei Wu, Xinliang Mao   +11 more
openaire   +2 more sources