Results 211 to 220 of about 20,395,316 (257)

Real‐world outcomes of daratumumab, bortezomib, thalidomide and dexamethasone (Dara‐VTd) induction and lenalidomide maintenance in transplant‐eligible multiple myeloma

British Journal of Haematology, EarlyView.
Edvan Q. Crusoé, Glaciano Ribeiro, João Tadeu D. Souto Filho, Jayr Schmidt Filho, Natalia Schutz, Milton A. F. Aranha, Abel Costa, Abrahao Hallack, Fernando V. Pericole, Juliana S. Lima, Breno Gusmão, Eduardo Flávio O. Ribeiro, Jorge P. Vaz, Rosane Bittencourt, Rafael Cunha, Danielle Ovigli, Luiza Berg, Ederson R. Mattos, Angelo Maiolino, Vania Hungria, on behalf of GBRAM   +20 more
wiley   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

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Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.

Blood, 2020
The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM) but how to achieve it is still elusive. In the present study we found the Otub1/c-Maf axis could be a potential target.
Yu-jia Xu, Min Xu, Jiefei Tong, Xiao-Wen Tang, Jin-Hao Chen, Xue-han Chen, Zubin Zhang, Biyin Cao, A. Stewart, M. Moran, De-Pei Wu, X. Mao   +11 more
semanticscholar   +3 more sources

Correlation between the expression level of c-maf and glutathione peroxidase-3 in c-maf −/− mice kidney and c-maf overexpressed renal tubular cells

Biochemical and Biophysical Research Communications, 2006
Large mafs are transcriptional factors and members of the basic leucine zipper (b-Zip) superfamily. Since we previously identified expression of c-maf in mouse kidney, we presently investigated the mRNA expression profile in the kidney of c-maf gene knockout mice by using DNA microarray, and plasma glutathione peroxidase-3 (GPx3) was predominantly ...
S, Shirota, T, Yoshida, M, Sakai, J I, Kim, H, Sugiura, T, Oishi, K, Nitta, K, Tsuchiya   +7 more
openaire   +2 more sources

Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver

Biochemical and Biophysical Research Communications, 2004
Maf is a family of oncogenes which encodes a nuclear bZip transcription factor protein and has been originally identified from the avian oncogenic retrovirus, AS42. Maf genes have been reported to have critical roles in embryological development and cellular differentiation.
Junko, Imaki, Ken, Tsuchiya, Takuya, Mishima, Hidetaka, Onodera, James I, Kim, Kazuhiko, Yoshida, Hiromi, Ikeda, Masaharu, Sakai   +7 more
openaire   +2 more sources

SUMOylation attenuates c-Maf-dependent IL-4 expression [PDF]

European Journal of Immunology, 2010
AbstractThe function of transcription factors can be critically regulated by SUMOylation. c‐Maf, the cellular counterpart of v‐maf oncogene, is a potent transactivator of the IL‐4 gene in Th2 cells. We found in a yeast two‐hybrid screen that c‐Maf can interact with Ubc9 and PIAS1, two key enzymes of the SUMOylation pathway.
Li-Fang Wang, Shi-Chuen Miaw, I-Cheng Ho
exaly   +3 more sources

A Chemical Biology Screen Identifies Glucocorticoids as Inhibitors of C-Maf and C-Maf-Dependent Transactivation of Cyclin D2.

Blood, 2006
Abstract The oncogene c-maf is frequently over-expressed in multiple myeloma cell lines and patient samples and contributes to increased cellular proliferation in part by inducing cyclin D2 expression. Therefore, small molecules that inhibit c-maf and its targets could be useful chemical probes to better understand the role and ...
MAO X., STEWART A. K., HURREN R., DATTI, Alessandro, SHI C. X., ZHU Y. X., LEE K., TIEDEMANN R., EBERHARD Y., COREY S. J., WRANA J., SCHIMMER A. D.   +11 more
openaire   +2 more sources

Variable Effects of Transgenic c-Maf on Autoimmune Diabetes

Diabetes, 2001
Autoimmune diabetes is associated with T helper 1 polarization, but protection from disease can be provided by the application of T helper 2 (Th2) cytokines. To test whether genetic manipulation of T-cells can provide protective Th2 responses, we developed transgenic mice in which T-cells express the interleukin-4-specific transcription factor c-Maf ...
M E, Pauza, A, Nguyen, T, Wolfe, I C, Ho, L H, Glimcher, M, von Herrath, D, Lo   +6 more
openaire   +2 more sources

c-Maf rules the island

Blood, 2011
In this issue of Blood , Kusakabe et al make a compelling case that the transcription factor c-Maf is critical for erythroblastic island formation and fetal erythropoiesis. 1 The cell adhesion molecule VCAM-1 is a potential mediator of c-Maf activity.
openaire   +2 more sources

TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf

Science immunology
T follicular helper (TFH) cells are essential for effective antibody responses, but deciphering the intrinsic wiring of mouse TFH cells has long been hampered by the lack of a reliable protocol for their generation in vitro.
Yinshui Chang, Luisa Bach, M. Hasiuk, Li-Fen Wen, T. Elmzzahi, Carlson Tsui, Nicolás Gutiérrez-Melo, Teresa Steffen, Daniel T. Utzschneider, Timsse Raj, P. J. Jost, Sylvia Heink, Jingyuan Cheng, Oliver T. Burton, Julia Zeiträg, Dominik Alterauge, Frank Dahlstroem, J. Becker, Melanie A. Kastl, K. Symeonidis, M. van Uelft, Matthias Becker, Sarah Reschke, S. Krebs, Helmut Blum, Z. Abdullah, K. Paeschke, C. Ohnmacht, C. Neumann, A. Liston, F. Meissner, Thomas Korn, J. Hasenauer, V. Heissmeyer, M. Beyer, A. Kallies, L. Jeker, Dirk Baumjohann   +37 more
semanticscholar   +1 more source