The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC. [PDF]
PLoS ONE, 2012 p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription.
Chang Kyoo Sung +8 more
doaj +6 more sources
Stem Cell Research & Therapy, 2019 Background Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of ...
Svitlana Melnik +6 more
doaj +2 more sources
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities. [PDF]
PLoS ONE, 2012 Although tumor-associated macrophages (TAMs) are involved in tumor growth and metastasis, the mechanisms controlling their pro-tumoral activities remain largely unknown.
Oscar M Pello +8 more
doaj +7 more sources
PDCD11 Stabilizes C‐MYC Oncoprotein by Hindering C‐MYC‐SKP2 Negative Feedback Loop to Facilitate Progression of p53‐Mutant Breast and Colon Malignancies [PDF]
Advanced ScienceC‐MYC is a proto‐oncoprotein whose dysregulation triggers tumorigenesis and tumor progression in ≈70% of cancer cases. It is presently demonstrated that aberrantly upregulated MYC is caused by the overexpressed and “extra‐nucleolar” PDCD11 in p53‐mutant ...
Li Ding +12 more
doaj +2 more sources
A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer [PDF]
Frontiers in GeneticsBackgroundProto-oncogenes are abnormally activated in nearly all types of tumors. However, the epigenetic mechanism of proto-oncogene activation has not yet been well elucidated.MethodsThe present study involved the construction of a double-stranded cDNA
Xuming Hu +19 more
doaj +2 more sources
Identification and validation of the role of c-Myc in head and neck squamous cell carcinoma
Frontiers in Oncology, 2022 BackgroundMany studies have shown that c-Myc plays a critical role in tumorigenesis. However, the molecular role of c-Myc in head and neck squamous cell carcinoma (HNSC) remains unclear.MethodsSeveral biological databases, including UALCAN, TIMER2.0 ...
Sufeng Zhao +5 more
doaj +1 more source
MYC is a metastasis gene for non-small-cell lung cancer. [PDF]
, 2009 Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Castro, Inês +8 more
core +15 more sources
c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment
Cell Communication and Signaling, 2023 The MYC oncogenic family is dysregulated in diverse tumors which is generally linked to the poor prognosis of tumors. The members in MYC family are transcription factors which are responsible for the regulation of various genes expression.
Fangyan Gao +4 more
semanticscholar +1 more source
Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8
Cancer Biology & Therapy, 2022 Overexpression of c-myc via increased transcription or decreased protein degradation is common to many cancer etiologies. c-myc protein degradation is mediated by ubiquitin-dependent degradation, and this ubiquitylation is regulated by several E3 ligases.
Sagar Bajpai +3 more
doaj +1 more source
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit
Acta Pharmaceutica Sinica B, 2022 The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes.
Xiaomeng Gao +10 more
doaj +1 more source