Results 101 to 110 of about 19,205,329 (382)

SUMO protease SENP1 deSUMOylates and stabilizes c-Myc

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance c-Myc is dynamically regulated by posttranslational modifications, including SUMOylation. However, how SUMOylation regulates c-Myc activity and stability remains elusive.
Xiao-Xin Sun, Yingxiao Chen, Yulong Su, Xiaoyan Wang, Krishna M. Chauhan, Juan Liang, Colin J. Daniel, R. Sears, M. Dai   +8 more
semanticscholar   +1 more source

Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes. [PDF]

, 2019
The germinal center (GC) is the anatomical site where humoral immunity evolves. B cells undergo cycles of proliferation and selection to produce high-affinity Abs against Ag. Direct linkage of a TLR9 agonist (CpG) to a T-dependent Ag increases the number
Ansel, K Mark, DeFranco, Anthony L, Wigton, Eric J   +2 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex

Nucleic Acids Research, 2018
The structural differences among different G-quadruplexes provide an opportunity for site-specific targeting of a particular G-quadruplex structure. However, majority of G-quadruplex ligands described thus far show little selectivity among different G ...
Debasish Dutta, M. Debnath, D. Müller, Rakesh Paul, T. Das, Irene Bessi, H. Schwalbe, J. Dash   +7 more
semanticscholar   +1 more source

Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo [PDF]

, 2016
Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of ...
Berek, Jonathan S, Chung, Young Min, Hu, Mickey C-T, Ma, Jessica, Park, See-Hyoung, Yang, Qin   +5 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours. [PDF]

, 2016
BACKGROUND: MYC is amplified in approximately 15% of breast cancers (BCs) and is associated with poor outcome. c-MYC protein is multi-faceted and participates in many aspects of cellular function and is linked with therapeutic response in BCs.
A Albihn, A Borg, A Sierra, AN Shajahan-Haq, Andrew R Green, B Li, C Adem, C Curtis, Cancer Genome Atlas Network, Carlos Caldas, Christopher C Nolan, CJ Sherr, CM McNeil, CM Schlotter, CV Dang, D Arango, D Ruggero, DA Gewirtz, DA Spandidos, Dai Horiuchi, Devika Agarwal, DJ Liao, DJ Liao, DM Abd El-Rehim, EA Dublin, EA Musgrove, EA Rakha, EA Rakha, EC Robanus-Maandag, EM Berns, EM Berns, Emad A Rakha, ES Knudsen, FC Schmitt, FF Barros, GF Santos, Graham R Ball, H Hernandez-Vargas, HO Habashy, Ian O Ellis, J Gray-Bablin, J Xu, JH Patel, JK Rummukainen, JS Carroll, JS Reis-Filho, K Al-Kuraya, K Alevizopoulos, L Guerra, L Shen, LE Janocko, LJ Lancashire, LM Mcshane, M Roux-Dosseto, M Smoot, M Venditti, M Vita, MA Aleskandarany, MA Aleskandarany, MA Aleskandarany, MA Aleskandarany, Maria Diez-Rodriguez, MD Planas-Silva, Mohammed A Aleskandarany, MV Nemtsova, N Palaskas, P Jezequel, P Liu, PL Barratt, PV Boddupally, R Agarwal, R Douglas Macmillan, R Naidu, R Nair, R Shanmugham, R Spaventi, S Aulmann, S Elsheikh, S Han, S Miura, SJ Nass, SL Deming, SM Rodriguez-Pinilla, Somaia Elsheikh, Srinivasan Madhusudan, T Hothorn, T Wahlstrom, TM Abdel-Fatah, Z Chen, Z Hu   +89 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease

Genes, 2017
Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is
K. Zheng, F. Cubero, Y. Nevzorova
semanticscholar   +1 more source

The positive transcriptional elongation factor (P-TEFb) is required for neural crest specification [PDF]

, 2016
Regulation of gene expression at the level of transcriptional elongation has been shown to be important in stem cells and tumour cells, but its role in the whole animal is only now being fully explored.
Adam E. Hendry, Anders, Andrea E. Münsterberg, Andrulis, Bai, Bellmeyer, Boettiger, Bowes, Bres, Buitrago-Delgado, Cheng, Christopher T. Ford, Core, Elworthy, Fuda, Fujita, Gaertner, Garcia-Morales, Gert Jan C. Veenstra, Grant N. Wheeler, Green, Grocott, Harrison, Heckmann, Hochheimer, Hontelez, Hoppler, Huang, Ila van Kruijsbergen, Ines Desanlis, Jallow, Jonkers, Kee, Keegan, Kohoutek, Langmead, Light, Lin, Lis, Luo, Marta Marin-Barba, Matthew L. Tomlinson, Milet, Nicole J. Ward, Nieuwkoop, Pegoraro, Rahl, Rahl, Rozen, Saartje Hontelez, Sauka-Spengler, Sauka-Spengler, Schlosser, Showell, Simon Moxon, Takahashi, Tomlinson, Tomlinson, Tomlinson, Tomlinson, Victoria L. Hatch, Wada, White, Williams, Yamaguchi, Zeitlinger, Zhou   +66 more
core   +1 more source