Results 181 to 190 of about 18,976,803 (305)

Crotonylation impedes c-Myc oncogenic activity. [PDF]

Proc Natl Acad Sci U S A
Wallbillich NJ, Liao P, Srivastava R, Fan J, Zeng SX, Lu H.   +5 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation. [PDF]

Cancer Sci
Wang K, Song W, Bai Q, Shen S, Lu X, Su C, Yang S, Wang Y, Xia Y, Zan R, Jiang S, Guo J.   +11 more
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review). [PDF]

Mol Med Rep
Lu J, Zhu J, Zhang L, Zheng X, Yang S, Sang Y, Yang M, Tang Y.   +7 more
europepmc   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

Evaluation of c-Myc in odontogenic cysts and tumours-An immunohistochemical study. [PDF]

J Oral Maxillofac Pathol
Pinisetti S, Vinaya NL, Adusumilli P, Babburi S, Venigalla A, Benarjee A.   +5 more
europepmc   +1 more source

Dissection of c-myc domains involved in S phase induction of NIH 3T3 fibroblasts

, 1994
The product of the c-myc proto-oncogene is an important regulator of cell proliferation and apoptosis in murine fibroblasts. Addition of the tumor promoter, phorbol myristate acetate (PMA), prevents apoptotic cell death induced by low serum ...
BRANCOLINI, Claudio, SCHNEIDER C, Gustincich, Stefano, BRANCOLINI C, LEE WMF, SCHNEIDER C., LEE W, GORUPPI S, GUSTINCICH S   +8 more
core  

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

RFC5 and STAT3 form a transcriptional complex to drive NSCLC progression via c-Myc. [PDF]

iScience
Yan J, Yi T, Tian W, Wu J, Yu R, Zhang S, Cheng Z, Di X, Jiang H, Wen D, Zhang S.   +10 more
europepmc   +1 more source