Cell Communication and Signaling, 2022 Background Transcription factor c-Myc plays a critical role in various physiological and pathological events. c-Myc gene rearrangement is closely associated with multiple myeloma (MM) progression and drug resistance.
Ruosi Yao +6 more
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Rabring7 degrades c-Myc through complex formation with MM-1. [PDF]
PLoS ONE, 2012 We have reported that a novel c-Myc-binding protein, MM-1, repressed E-box-dependent transcription and transforming activities of c-Myc and that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of ...
Rina Narita +6 more
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c-Myc accelerates S-phase and requires WRN to avoid replication stress. [PDF]
PLoS ONE, 2009 c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown.
Kristin Robinson +3 more
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Overexpression of c-Myc and cell immortalization alters c-Myc phosphorylation [PDF]
Oncogene, 1997 Using an extensive series of deletion and site-specific mutation constructs, we have identified five new phosphorylation sites in c-Myc in the N-terminal transactivation domain and near the C-terminal DNA binding/heterodimerization domain. We have also found that Thr-58 phosphorylation is regulated by specific cellular events.
B, Lutterbach, S R, Hann
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Molecular and functional characterization of the interaction between c-Myc and the MCM helicase [PDF]
, 2006 The Myc genes (c-myc, n-myc, l-myc, s-myc) encode a family of protein that share structural an biological features and are conserved across all Metazoans.
Ruggiero, Luca
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Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis [PDF]
, 2004 Background Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes.
Abouna, Sylvie +11 more
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Global regulation of nucleotide biosynthetic genes by c-Myc. [PDF]
PLoS ONE, 2008 The c-Myc transcription factor is a master regulator and integrates cell proliferation, cell growth and metabolism through activating thousands of target genes.
Yen-Chun Liu +8 more
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Apoptotic signaling by c-MYC [PDF]
Oncogene, 2008 c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes cells to apoptosis by a variety of stimuli. The decision of a cell to undergo apoptosis and how this apoptotic response is regulated by c-MYC depends on the specific cell type and ...
B, Hoffman, D A, Liebermann
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Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner. [PDF]
PLoS ONE, 2013 The transcription factors Runx1 and c-Myc have individually been shown to regulate important gene targets as well as to collaborate in oncogenesis. However, it is unknown whether there is a regulatory relationship between the two genes. In this study, we
Paejonette T Jacobs +6 more
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Physiological roles of the oncoprotein c-Myc in mouse mammary gland development [PDF]
, 2009 c-Myc, a transcription factor that affects a large number of target genes, is one of the most frequently deregulated oncoproteins in human cancer. The wide-ranging biological functions of c-Myc include regulation of the cell cycle, differentiation ...
Stölzle, Tina
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