Results 11 to 20 of about 14,797,528 (308)
Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc
International Journal of Hyperthermia, 2022 Background Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. Objective We hypothesized that
Xiaole Li +9 more
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Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis [PDF]
Journal of Experimental & Clinical Cancer Research, 2018 Background The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy ...
Matteo Caforio +5 more
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Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc
Scientific Reports, 2023 c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or highly expressed in cancers. However, molecular mechanisms underlying this aberrantly high expression remain unclear.
Takahiro Masaki +6 more
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Cell Communication and Signaling, 2022 Background Transcription factor c-Myc plays a critical role in various physiological and pathological events. c-Myc gene rearrangement is closely associated with multiple myeloma (MM) progression and drug resistance.
Ruosi Yao +6 more
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Rabring7 degrades c-Myc through complex formation with MM-1. [PDF]
PLoS ONE, 2012 We have reported that a novel c-Myc-binding protein, MM-1, repressed E-box-dependent transcription and transforming activities of c-Myc and that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of ...
Rina Narita +6 more
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Overexpression of c-Myc and cell immortalization alters c-Myc phosphorylation [PDF]
Oncogene, 1997 Using an extensive series of deletion and site-specific mutation constructs, we have identified five new phosphorylation sites in c-Myc in the N-terminal transactivation domain and near the C-terminal DNA binding/heterodimerization domain. We have also found that Thr-58 phosphorylation is regulated by specific cellular events.
B, Lutterbach, S R, Hann
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Global regulation of nucleotide biosynthetic genes by c-Myc. [PDF]
PLoS ONE, 2008 The c-Myc transcription factor is a master regulator and integrates cell proliferation, cell growth and metabolism through activating thousands of target genes.
Yen-Chun Liu +8 more
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Apoptotic signaling by c-MYC [PDF]
Oncogene, 2008 c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes cells to apoptosis by a variety of stimuli. The decision of a cell to undergo apoptosis and how this apoptotic response is regulated by c-MYC depends on the specific cell type and ...
B, Hoffman, D A, Liebermann
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Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis [PDF]
, 2004 Background Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes.
Abouna, Sylvie +11 more
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c-Myc accelerates S-phase and requires WRN to avoid replication stress. [PDF]
PLoS ONE, 2009 c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown.
Kristin Robinson +3 more
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