Results 61 to 70 of about 282,611 (163)

Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress

Cell Reports, 2013
c-Myc oncogenic activity is thought to be mediated in part by its ability to generate DNA replication stress and subsequent genomic instability when deregulated.
Seetha V. Srinivasan, David Dominguez-Sola, Lily C. Wang, Olivier Hyrien, Jean Gautier   +4 more
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Anti-c-myc efficacy block EGFL7 induced prolactinoma tumorigenesis

Open Chemistry, 2019
Resistance to Dopamine agonists therapy is still a key factor that hinders the clinical treatment of prolactinoma. Consequently, a large number of investigations have been carried out to identify novel therapeutic targets.
Lan Xiaolei, Liu Qian, Gao Hua, Li Zhenye, Zhang Yazhuo   +4 more
doaj   +1 more source

The role of c-Myc-RBM38 loop in the growth suppression in breast cancer

Journal of Experimental & Clinical Cancer Research, 2017
Background RNA-binding protein 38 (RBM38) is a member of the RNA recognition motif (RRM) family of RNA-binding proteins (RBPs). RBM38 often exerts its function by forming regulatory loops with relevant genes.
Xiao-Xia Li, Liang Shi, Xu-Jie Zhou, Jing Wu, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Lei Zhu, Ji-Fu Wei, Qiang Ding   +9 more
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Differentiation-Inducing Factor-1 Suppresses the Expression of c-Myc in the Human Cancer Cell Lines

Journal of Pharmacological Sciences, 2013
Differentiation-inducing factor-1 (DIF-1), a morphogen for Dictyostelium discoideum, inhibits the proliferation of human cancer cell lines by suppressing the Wnt/β-catenin signaling pathway.
Kentaro Jingushi, Toshihisa Nakamura, Fumi Takahashi-Yanaga, Etsuko Matsuzaki, Yutaka Watanabe, Tatsuya Yoshihara, Sachio Morimoto, Toshiyuki Sasaguri   +7 more
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c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells

BMC Cancer, 2011
Background The BRCA1 gene plays an important role in the maintenance of genomic stability. BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to regulate BRCA1 expression.
Huo Dezheng, Collins Cindy, Borowicz Stanley, Xu Jinhua, Chen Yinghua, Olopade Olufunmilayo I   +5 more
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USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer

Cell Death and Disease
A hallmark of tumor cells, including bladder cancer (BLCA) cells, is metabolic reprogramming toward aerobic glycolysis (Warburg effect). The classical oncogene MYC, which is crucial in regulating glycolysis, is amplified and activated in BLCA.
Mingxing Li, Jingtian Yu, Lingao Ju, Yejinpeng Wang, Wan Jin, Renjie Zhang, Wan Xiang, Meng Ji, Wenzhi Du, Gang Wang, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +13 more
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C-myc Expression in the Microvessels of Medulloblastoma

Collegium antropologicum, 2011
The increased expression of c-myc is related to neoplastic transformation and angiogenesis. Therefore, the assessment of expression of c-myc in endothelial cells and neovascularization could help to determine the biological behavior of the tumor. We analyzed neovascularization and c-myc expression in 36 medulloblastoma specimens. The results were shown
Stanić, Gabrijela, Čupić, Hrvoje, Žarković, Kamelija, Tomas, Davor, Krušlin, Božo   +4 more
openaire   +4 more sources

c-Myc Drives inflammation of the maternal-fetal interface, and neonatal lung remodeling induced by intra-amniotic inflammation

Frontiers in Cell and Developmental Biology
Background: Intra-amniotic inflammation (IAI) is associated with increased risk of preterm birth and bronchopulmonary dysplasia (BPD), but the mechanisms by which IAI leads to preterm birth and BPD are poorly understood, and there are no effective ...
April W. Tan, Xiaoying Tong, Silvia Alvarez-Cubela, Pingping Chen, Aline Guimarães Santana, Alejo A. Morales, Runxia Tian, Rae Infante, Vanessa Nunes de Paiva, Shathiyah Kulandavelu, Shathiyah Kulandavelu, Merline Benny, Juan Dominguez-Bendala, Shu Wu, Karen C. Young, Claudia O. Rodrigues, Claudia O. Rodrigues, Claudia O. Rodrigues, Augusto F. Schmidt   +18 more
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c-Myc [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

The mechanism of c-Myc expression regulated by T cell protein p80

四川大学学报. 自然科学版, 2019
Our experimental data indicate that overexpression of p80 in p80 null T cell leukemia cells significantly down regulates c-Myc oncoprotein and blocks cell cycle progression from G1 to S phase.
WANG Qiao, ZHANG Yu-Jun, JIANG Xian-Jie
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