Results 41 to 50 of about 278,570 (263)

Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions [PDF]

Genes & Cancer, 2010
The coding region determinant binding protein, CRD-BP, is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, and localization. It is mostly expressed in fetal and neonatal tissues, where it regulates many transcripts essential for normal embryonic development.
Felicite K, Noubissi, Mikhail A, Nikiforov, Nancy, Colburn, Vladimir S, Spiegelman   +3 more
openaire   +2 more sources

c-MYC and Epithelial Ovarian Cancer [PDF]

Frontiers in Oncology, 2021
Ovarian cancer is the deadliest of gynecological malignancies with approximately 49% of women surviving 5 years after initial diagnosis. The standard of care for ovarian cancer consists of cytoreductive surgery followed by platinum-based combination chemotherapy.
Jeyshka M. Reyes-González, Pablo E. Vivas-Mejía, Pablo E. Vivas-Mejía   +2 more
openaire   +3 more sources

Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis [PDF]

Oncogene, 2000
Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression.
T L, Timme, A, Goltsov, S, Tahir, L, Li, J, Wang, C, Ren, R N, Johnston, T C, Thompson   +7 more
openaire   +2 more sources

In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities. [PDF]

PLoS ONE, 2012
Although tumor-associated macrophages (TAMs) are involved in tumor growth and metastasis, the mechanisms controlling their pro-tumoral activities remain largely unknown.
Oscar M Pello, Raphael Chèvre, Damya Laoui, Alba De Juan, Fidel Lolo, María Jesús Andrés-Manzano, Manuel Serrano, Jo A Van Ginderachter, Vicente Andrés   +8 more
doaj   +1 more source

FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity [PDF]

Journal of Biological Chemistry, 2015
FBXO32 (MAFbx/Atrogin-1) is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. Although some data indicate that FBXO32 may play an important role in tumorigenesis, the molecular mechanism of FBXO32 in tumorigenesis has been poorly understood.
Zhichao, Mei, Dawei, Zhang, Bo, Hu, Jing, Wang, Xian, Shen, Wuhan, Xiao   +5 more
openaire   +2 more sources

Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation [PDF]

Blood, 2019
Gfi1 is a zinc-finger transcriptional repressor that plays an important role in hematopoiesis. When aberrantly activated, Gfi1 may function as a weak oncoprotein in the lymphoid system, but collaborate strongly with c-Myc in lymphomagenesis. c-Myc is a transcription factor that is frequently activated in human cancers including leukemia and lymphoma ...
Zhang, Yangyang, Dong, Fan
openaire   +2 more sources

Getting to grips with c-Myc [PDF]

eLife, 2018
The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Antitumor Effect of Anti‐c‐Myc Aptamer‐Based PROTAC for Degradation of the c‐Myc Protein

Advanced Science
Targeting “undruggable” targets with intrinsically disordered structures is of great significance for the treatment of disease. The transcription factor c‐Myc controls global gene expression and is an attractive therapeutic target for multiple types of ...
Yuchun Wang, Gang Yang, Xinyu Zhang, Ruoling Bai, Deyu Yuan, Denghui Gao, Qianyu He, Yi Yuan, Xinghe Zhang, Junchuang Kou, Lihua Zheng, Yanxin Huang, Zhuo Tang, Yongli Bao, Xu Song, Yongyun Zhao   +15 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source