Results 171 to 180 of about 14,797,528 (308)

Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer

Cancer stem cells (CSCs) are cancer cells responsible for cancer initiation, growth, metastasis, recurrence and resistance to treatment. OCT4 and c-MYC are widely accepted as CSC markers.
Gökmen Aktaş, Neslihan Kurtul, Rabia Hursitoglu, Sezen Koçarslan, Emine Kılınç, Abdulkadir Yasir Bahar   +5 more
core   +1 more source

Oncogene c‑Myc: From molecular mechanism to targeted therapy (Review). [PDF]

Mol Med Rep
Lu J, Zhu J, Zhang L, Zheng X, Yang S, Sang Y, Yang M, Tang Y.   +7 more
europepmc   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

PTTG1-mediated the transcription of c-myc promotes retinoblastoma progression. [PDF]

Cell Div
Feng J, Ye Y, Cheng F, Wu Y.
europepmc   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Myc-overexpression increases Rer1 levels to maintain proteostasis.

(A) Images of wing discs with hh-Gal4 driven Myc-overexpression, observed with anti-Myc staining (A”), in GFP-rer1 background (GFP-rer1; hh-Gal4::UAS-RFP-KDEL + UAS-Myc; N = 10 wing discs) show higher levels of GFP-Rer1 in the posterior compartment as ...
Shruti Umarvaish (18056496), Shivani Bajaj (18056499), Varun Chaudhary (37352), Hrudya Mohan (18056505), Pranab Kumar Paul (18056493), Rishana Farin S. (18056502), Wim Annaert (29167)   +6 more
core   +1 more source

Omacetaxine reduces c-Myc expression and demonstrates antitumor effects in osteosarcoma. [PDF]

Sci Rep
Farrell KB, Das S, Thamm DH.
europepmc   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

MAGEC2 promotes tumorigenesis in multiple myeloma through USP16-mediated deubiquitination and stabilization of c-Myc. [PDF]

Exp Hematol Oncol
Liu Z, Hu T, Min J, Wang C, Cao Y, Guo M, Qian J, Gu C, Yang Y.   +8 more
europepmc   +1 more source