Results 111 to 120 of about 18,976,803 (305)
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
, 2011 Copyright information:Taken from "Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis"BMC Biology 2004;2():26-26.Published online 21 Dec 2004PMCID:PMC544575.Copyright ...
Sevasti Zervou (71022) +5 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress
Cell Reports, 2013 c-Myc oncogenic activity is thought to be mediated in part by its ability to generate DNA replication stress and subsequent genomic instability when deregulated.
Seetha V. Srinivasan +4 more
doaj +1 more source
Overexpression of Cyclin D1 and C-Myc Gene Products in Human Primary Epithelial Ovarian Cancer
, 2009 Cyclin D1 and c-Myc are key participants in the cell-cycle pathway, in which aberrancies have been associated with malignant transformation. To date, data on the relationship of expression of these proteins and histologic subtype of epithelial ovarian ...
周松男 +1 more
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, 2011 C: LightCycler). Fold changes are shown on the y-axis. Significant changes of gene expression are indicated either with a diamond for array analysis or with an asterisk for real time PCR.Copyright information:Taken from "Transcription profiling of lung ...
Susanne Reymann (56981) +1 more
core +1 more source
Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity [PDF]
, 1997 The c-myc gene encodes a sequence-specific DNA binding protein involved in proliferation and oncogenesis. Activation of c-myc expression in quiescent cells is sufficient to mediate cell cycle entry, whereas inhibition of c-myc expression causes cycling ...
Bernards, R.A., Hijmans, E.M., Berns, K.
core +1 more source
, 2022 Additional file 2: Figure S2. RNF180 silencing contributed to the expression of C-myc through inhibiting its ubiquitination. A and B. Western blot was used to examine the protein level of C-myc in siNC and siRNF180 transfecting H292 and A549 with or ...
Yi Ding (172783) +4 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Life or cell death: identifying c-Myc regulated genes in two distinct tissues [PDF]
The c-myc oncogene is over-expressed or deregulated in many human cancers. c-myc encodes a transcription factor, the oncoprotein c-Myc (Myc), which acts as a master regulator of genes involved in such diverse cellular processes as replication and growth,
Robson, Samuel Charles
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