Results 41 to 50 of about 18,976,803 (305)

Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]

, 2014
This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Edward V Prochownik, Inga Müller, Oliynyk, G, Ganna Oliynyk (568258), Zirath Hanna, Prochownik Edward V., Larsson, Karin, Anna Frenzel, Marie Arsenian Henriksson, Anna Frenzel (194997), Edward V. Prochownik (163628), Henriksson, MA, Westwood Nicholas J., Oliynyk, Ganna, Hanna Zirath, Marie Arsenian Henriksson (195006), Oliynyk Ganna, Ganna Oliynyk, Larsson, K, Frenzel, A, Frenzel, Anna, Zirath, Hanna, Prochownik, Edward V., Nicholas J Westwood, Frenzel Anna, Zirath, H, Henriksson Marie Arsenian, Karin Larsson, Muller, Inga, Nicholas J. Westwood, Inga Müller (568256), Nicholas J. Westwood (254891), Edward V. Prochownik, Müller, I, Westwood, NJ, Müller Inga, Henriksson, Marie Arsenian, Karin Larsson (568257), Hanna Zirath (195000), Prochownik, EV, Westwood, Nicholas J., Larsson Karin, Oliynyk, G,, Larsson, K,   +43 more
core   +2 more sources

c-myc Amplification Is Frequent in Esophageal Adenocarcinoma and Correlated with the Upregulation of VEGF-A Expression

Neoplasia: An International Journal for Oncology Research, 2006
BACKGROUND: Deregulation of c-myc plays a major role in the carcinogenesis of human malignancies. We investigated the amplification of the c-myc gene in a surgical series of Barrett cancers. METHODS: Primary resected esophageal (Barrett) adenocarcinomas (
Burkhard H.A. von Rahden, Hubert J. Stein, Franziska Pühringer-Oppermann, Mario Sarbia   +3 more
doaj   +1 more source

The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC. [PDF]

PLoS ONE, 2012
p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription.
Chang Kyoo Sung, Hyungshin Yim, Hongcang Gu, Dawei Li, Erik Andrews, Sekhar Duraisamy, Cheng Li, Ronny Drapkin, Thomas Benjamin   +8 more
doaj   +1 more source

MYC is a metastasis gene for non-small-cell lung cancer. [PDF]

, 2009
Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Christian Korn, Emanuele Zanucco, Potapenko, Tamara, Korn, C., Zanucco, E., Castro, I., Inês Castro, Fatih Ceteci, Potapenko, T., Ceteci, F., Rapp, Ulf R., Luetkenhaus, Katharina, Ulf R Rapp, Korn, Christian, Tamara Potapenko, Serafin, V., Christiaan Karreman, Castro, Inês, Luetkenhaus, K., Ceteci, Fatih, Zanucco, Emanuele, Valentina Serafin, Karreman, Christiaan, Karreman, C., Serafin, Valentina, Katharina Luetkenhaus, Rapp, U. R.   +26 more
core   +2 more sources

Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions [PDF]

Genes & Cancer, 2010
The coding region determinant binding protein, CRD-BP, is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, and localization. It is mostly expressed in fetal and neonatal tissues, where it regulates many transcripts essential for normal embryonic development.
Felicite K, Noubissi, Mikhail A, Nikiforov, Nancy, Colburn, Vladimir S, Spiegelman   +3 more
openaire   +2 more sources

PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. [PDF]

, 2007
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero, Serafini, Riccardo, Riccardo Serafini, Alessandra De Robertis, Alessio Zippo, De Robertis, Alessandra, Zippo, Alessio, Oliviero, Salvatore   +7 more
core   +1 more source

c-Myc Suppression of DNA Double-strand Break Repair

Neoplasia: An International Journal for Oncology Research, 2012
c-Myc is a transcriptional factor that functions as a central regulator of cell growth, proliferation, and apoptosis. Overexpression of c-Myc also enhances DNA double-strand breaks (DSBs), genetic instability, and tumorigenesis. However, the mechanism(s)
Zhaozhong Li, Taofeek K. Owonikoko, Shi-Yong Sun, Suresh S. Ramalingam, Paul W. Doetsch, Zhi-Qiang Xiao, Fadlo R. Khuri, Walter J. Curran, Xingming Deng   +8 more
doaj   +1 more source

Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis [PDF]

Oncogene, 2000
Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression.
T L, Timme, A, Goltsov, S, Tahir, L, Li, J, Wang, C, Ren, R N, Johnston, T C, Thompson   +7 more
openaire   +2 more sources

Obesity under the moonlight of c-MYC

, 2023
The moonlighting protein c-Myc is a master regulator of multiple biological processes including cell proliferation, differentiation, angiogenesis, apoptosis and metabolism.
Cubero, Francisco Javier, Nevzorova, Yulia A, Nevzorova, Yulia, Cubero Palero, Francisco Javier   +3 more
core   +1 more source

FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity [PDF]

Journal of Biological Chemistry, 2015
FBXO32 (MAFbx/Atrogin-1) is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. Although some data indicate that FBXO32 may play an important role in tumorigenesis, the molecular mechanism of FBXO32 in tumorigenesis has been poorly understood.
Zhichao, Mei, Dawei, Zhang, Bo, Hu, Jing, Wang, Xian, Shen, Wuhan, Xiao   +5 more
openaire   +2 more sources