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Function of the c‐Myc oncoprotein
The FASEB Journal, 1992The c‐Myc protein, the product of the c‐myc proto‐oncogene, is a nuclear phosphoprotein with DNA binding properties. Deregulated c‐myc expression participates in the development of experimentally induced tumors, and its expression appears to be abnormal
G J, Kato, C V, Dang
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Archives of Biochemistry and Biophysics, 2003
The proto-oncogene c-MYC is implicated in various physiological processes-cell growth, proliferation, loss of differentiation, and cell death (apoptosis). Oncogenic c-MYC implies constitutive or deregulated expression of c-MYC and is associated with many human cancers often with poor prognosis.
Stella, Pelengaris, Mike, Khan
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The proto-oncogene c-MYC is implicated in various physiological processes-cell growth, proliferation, loss of differentiation, and cell death (apoptosis). Oncogenic c-MYC implies constitutive or deregulated expression of c-MYC and is associated with many human cancers often with poor prognosis.
Stella, Pelengaris, Mike, Khan
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1990
Deregulated expression of c-myc secondary to chromosomal alterations is a constant feature of mouse plasmacytomas, rat immunocytomas and human Burkitt lymphomas (Mushinski, 1988). One feature of deregulated expression of c-myc is that all plasmacytomas have high levels of c-myc transcripts, no matter whether their chromosome 15 was interrupted by a ...
J F, Mushinski +4 more
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Deregulated expression of c-myc secondary to chromosomal alterations is a constant feature of mouse plasmacytomas, rat immunocytomas and human Burkitt lymphomas (Mushinski, 1988). One feature of deregulated expression of c-myc is that all plasmacytomas have high levels of c-myc transcripts, no matter whether their chromosome 15 was interrupted by a ...
J F, Mushinski +4 more
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Activation of the c-myc Oncogene
1986Activated forms of the c-myc oncogene have been linked to cell transformation in a variety of mammalian and avian tumors. Several mechanisms of gene activation have been described, but each mechanism gives rise to constitutive levels of expression, usually no higher than that found in proliferating normal cells.
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1995
G, Packham, J L, Cleveland
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G, Packham, J L, Cleveland
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2019
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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis
Cancer Cell, 2020Yonghua Sun, Xiaofan Zhu, Wuhan Xiao
exaly

