Results 81 to 90 of about 19,205,329 (382)

PA2G4 Functions as a Cofactor for MYC Family Oncoproteins in MYC-Driven Malignancies

Cells
MYCN and c-MYC are critical driver oncogenes in several childhood cancers, including neuroblastoma. Currently, the clinical development of MYC inhibitors has been hindered by the intrinsically disordered structure of MYC proteins, which lack well-defined
Sukriti Krishan, Jessica Koach, Taylor Lim, Kenny Yeo, Faith Cheong, Jie-Si Luo, Hassina Massudi, Xiaomian Gao, Sopheakwealthy Heangsarath, Andrew J. Kueh, Marco J. Herold, Belamy B. Cheung, Glenn M. Marshall   +12 more
doaj   +1 more source

Estrogen Induces c-myc Transcription by Binding to Upstream ERE Element in Promoter

Applied Sciences, 2022
Estrogen Receptor α(ERα) is reported to regulate the expression of many target genes by binding to specific estrogen response elements (EREs) in their promoters.
Nazia Rehman, Shahrukh Khan, Shumaila Manzoor, Muhammad Abubakar, Rokayya Sami, Saif A. Alharthy, Roua S. Baty, Ibrahim Jafri, Nouf H. Alsubhi, Sameer H. Qari, Ramla Shahid   +10 more
doaj   +1 more source

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

Nature Communications, 2017
The roles of long non-coding RNAs in cancer metabolism remain largely unexplored. Here we identify FILNC1 (FoxO-induced long non-coding RNA 1) as an energy stress-induced long non-coding RNA by FoxO transcription factors.
Zhen-Dong Xiao, Leng Han, Hyemin Lee, Zhuang Li, Yilei Zhang, Joelle A Baddour, Deepak Nagrath, C. Wood, J. Gu, Xifeng Wu, Han Liang, B. Gan   +11 more
semanticscholar   +1 more source

MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. [PDF]

, 2020
The metabolic switch from oxidative phosphorylation to glycolysis is required for tumorigenesis in order to provide cancer cells with energy and substrates of biosynthesis.
Chen, Wancheng, Dou, Wenlong, Feng, Bingbing, Fu, Xuemei, He, Yang-Fan, Ji, Kai-Yuan, Jiang, Lei, Kim, Jinchul, Li, Qingjiao, Mai, Taoyi, Tang, Qingshuang, Xiang, Le-Yang, XU, Yang, Yang, Dinghua, Ying, Yue, Yu, Lili, Zhou, Jianlong   +16 more
core   +1 more source

Pathway-based expression profiling of benign prostatic hyperplasia and prostate cancer delineates an immunophilin molecule associated with cancer progression [PDF]

, 2017
Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to ARreactivation should provide the foundation for novel avenues of
A Chatterjee, A Menssen, A Mondal, AE Leon, AL Gartel, AL Gartel, AT Reutens, B Kwabi-Addo, C Foley, C Kaltz-Wittmer, CE Petre-Draviam, CG Roehrborn, CM Coutinho-Camillo, CM Moore, D Bernard, E Wolf, ED Martinez, FH Sarkar, G Jenster, HA Coller, J Cheung-Flynn, JC Sivils, JF Lin, JG Scammell, JW Kim, K Davalieva, K Fizazi, KE Knudsen, KI Zeller, L Gao, NC Guy, NN Nupponen, Q Wang, RF Gittes, S Lu, S Lu, S Majumder, S Periyasamy, S Vignera La, SM Dehm, TD Elo, TH Davies, TJ Dorkin, VJ Gnanapragasam, W Yong, Y Chen, YS Kim   +46 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression

Cell Death and Disease, 2021
Dysregulation of transforming growth factor-beta (TGFβ) signaling has been implicated in liver carcinogenesis with both tumor promoting and inhibiting activities.
Haichuan Wang, Pan Wang, Meng Xu, Xinhua Song, Hong Wu, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen   +8 more
doaj   +1 more source

Alternative c-MYC mRNA Transcripts as an Additional Tool for c-Myc2 and c-MycS Production in BL60 Tumors

Biomolecules, 2022
While studying c-Myc protein expression in several Burkitt lymphoma cell lines and in lymph nodes from a mouse model bearing a translocated c-MYC gene from the human BL line IARC-BL60, we surprisingly discovered a complex electrophoretic profile. Indeed,
Dina Ibrahim, Léa Prévaud, Nathalie Faumont, Danielle Troutaud, Jean Feuillard, Mona Diab-Assaf, Ahmad Oulmouden   +6 more
doaj   +1 more source

The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects

Genes, 2017
c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis.
Lynh Nguyen, P. Papenhausen, Haipeng Shao   +2 more
semanticscholar   +1 more source

c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production [PDF]

, 2017
The mRNA cap is a structure added to RNA pol II transcripts in eukaryotes, which recruits factors involved in RNA processing, nuclear export and translation initiation. RNA guanine-7 methyltransferase (RNMT)–RNA-activating miniprotein (RAM), the mRNA cap
Arabi, Aregger, Cleveland, Cole, Cowling, Fernandez-Sanchez, Furuichi, Glover-Cutter, Gomez-Roman, Gonatopoulos-Pournatzis, Gonatopoulos-Pournatzis, Gonzalez, Grandori, Grasso, Grewal, Hann, Kress, Lombardi, Mayan, O'Sullivan, O'Sullivan, Olivia Lombardi, Ramanathan, Shatkin, Shuman, Shuman, Sianadh Dunn, Topisirovic, Varshney, Victoria H. Cowling, White   +30 more
core   +3 more sources