Results 41 to 50 of about 282,710 (262)

c-Myc Suppression of DNA Double-strand Break Repair

Neoplasia: An International Journal for Oncology Research, 2012
c-Myc is a transcriptional factor that functions as a central regulator of cell growth, proliferation, and apoptosis. Overexpression of c-Myc also enhances DNA double-strand breaks (DSBs), genetic instability, and tumorigenesis. However, the mechanism(s)
Zhaozhong Li, Taofeek K. Owonikoko, Shi-Yong Sun, Suresh S. Ramalingam, Paul W. Doetsch, Zhi-Qiang Xiao, Fadlo R. Khuri, Walter J. Curran, Xingming Deng   +8 more
doaj   +1 more source

Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis [PDF]

Oncogene, 2000
Recent data indicating that overexpression of caveolin-1 as well as c-myc are relatively common features of advanced prostate cancer prompted us to test for potential cooperative interactions between caveolin-1 and c-myc that would be consistent with malignant progression.
T L, Timme, A, Goltsov, S, Tahir, L, Li, J, Wang, C, Ren, R N, Johnston, T C, Thompson   +7 more
openaire   +2 more sources

FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity [PDF]

Journal of Biological Chemistry, 2015
FBXO32 (MAFbx/Atrogin-1) is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. Although some data indicate that FBXO32 may play an important role in tumorigenesis, the molecular mechanism of FBXO32 in tumorigenesis has been poorly understood.
Zhichao, Mei, Dawei, Zhang, Bo, Hu, Jing, Wang, Xian, Shen, Wuhan, Xiao   +5 more
openaire   +2 more sources

Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation [PDF]

Blood, 2019
Gfi1 is a zinc-finger transcriptional repressor that plays an important role in hematopoiesis. When aberrantly activated, Gfi1 may function as a weak oncoprotein in the lymphoid system, but collaborate strongly with c-Myc in lymphomagenesis. c-Myc is a transcription factor that is frequently activated in human cancers including leukemia and lymphoma ...
Zhang, Yangyang, Dong, Fan
openaire   +2 more sources

Mechanisms of apoptosis by c-Myc [PDF]

Oncogene, 1999
Much recent research on c-Myc has focused on how it drives apoptosis. c-Myc is widely known as a crucial regulator of cell proliferation in normal and neoplastic cells, but until relatively recently its apoptotic properties, which appear to be intrinsic, were not fully appreciated. Its death-dealing aspects have gained wide attention in part because of
openaire   +2 more sources

c-Myc regulates cell proliferation during lens development. [PDF]

PLoS ONE, 2014
Myc protooncogenes play important roles in the regulation of cell proliferation, growth, differentiation and survival during development. In various developing organs, c-myc has been shown to control the expression of cell cycle regulators and its ...
Gabriel R Cavalheiro, Gabriel E Matos-Rodrigues, Anielle L Gomes, Paulo M G Rodrigues, Rodrigo A P Martins   +4 more
doaj   +1 more source

Getting to grips with c-Myc [PDF]

eLife, 2018
The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Antitumor Effect of Anti‐c‐Myc Aptamer‐Based PROTAC for Degradation of the c‐Myc Protein

Advanced Science
Targeting “undruggable” targets with intrinsically disordered structures is of great significance for the treatment of disease. The transcription factor c‐Myc controls global gene expression and is an attractive therapeutic target for multiple types of ...
Yuchun Wang, Gang Yang, Xinyu Zhang, Ruoling Bai, Deyu Yuan, Denghui Gao, Qianyu He, Yi Yuan, Xinghe Zhang, Junchuang Kou, Lihua Zheng, Yanxin Huang, Zhuo Tang, Yongli Bao, Xu Song, Yongyun Zhao   +15 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source