Results 91 to 100 of about 78,879 (253)

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Adiponectin is associated with cardiovascular disease in male renal transplant recipients: baseline results from the LANDMARK 2 study

BMC Nephrology, 2009
Background Adiponectin is a major adipocyte-derived protein with insulin-sensitizing, anti-inflammatory and anti-atherogenic properties. Adiponectin levels correlate inversely with renal function and higher levels are predictive of lower cardiovascular ...
Mudge David, Campbell Scott, Hawley Carmel, Armstrong Kirsty, Kaisar Mohd O, Johnson David W, Prins John B, Isbel Nicole M   +7 more
doaj   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Effects of 6-month eicosapentaenoic acid treatment on postprandial hyperglycemia, hyperlipidemia, insulin secretion ability, and concomitant endothelial dysfunction among newly-diagnosed impaired glucose metabolism patients with coronary artery disease. An open label, single blinded, prospective randomized controlled trial [PDF]

, 2016
Additional file 2: Table S2. Comparison of cookie meal test data between baseline and 6 months, and comparison of absolute change from baseline among patients with baseline plasma glucose
Akira Shimane, Hideo Tsubata, Hiroya Kawai, Kiminobu Yokoi, Kosuke Aoki, Michinori Takabe, Mitsuhiro Yokoyama, Naoko Hashimoto, Shogo Oishi, Soichiro Yamashita, Taishi Miyata, Takahiro Sawada, Takeshi Ohara, Tetsuari Onishi, Tsuyoshi Osue, Yasue Tsukishiro, Yasuyo Taniguchi, Yoshinori Yasaka   +17 more
core   +4 more sources

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

A rebuttal--the Rsal polymorphism in the alpha-fibrinogen gene and response of plasma fibrinogen to physical training. [PDF]

, 2001
Cook, D, Davey, G, McKeigue, P
core   +5 more sources

Association between the CRP–TyG index and lupus nephritis risk

Biomolecules & Biomedicine
Assessment of insulin resistance is increasingly emphasized in patients with systemic lupus erythematosus (SLE) due to its significant role in predicting kidney injury and cardiovascular risk.
Baozhu Liang, Ming Tang, Junqi Huang, Yingfei Li, Rongmei Liang, Zeqing Zhai, Erwei Sun   +6 more
doaj   +1 more source

Peroxiredoxin 4, a novel circulating biomarker for oxidative stress and the risk of incident cardiovascular disease and all-cause mortality [PDF]

, 2012
BACKGROUND: Oxidative stress has been suggested to play a key role in the development of cardiovascular disease (CVD). The aim of our study was to investigate the associations of serum peroxiredoxin 4 (Prx4), a hydrogen peroxide-degrading peroxidase ...
Abbasi, A., Bakker, S.J., Beulens, J.W., Corpeleijn, E., de Jong, P.E., Gans, R.O., Gansevoort, R.T., Hillege, H.L., Navis, G., Peelen, L.M., Postmus, D., Schulte, J., Stolk, R.P., Struck, J., van der Harst, P.   +14 more
core   +2 more sources

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Serum cystatin C and chemerin levels in diabetic retinopathy [PDF]

, 2017
Peer reviewedPublisher ...
Chen, Xuedong, Li, Qingjun, Yu, Tian, Yu, Yongbin, Zhang, Liqiong, Zhao, Shiyong   +5 more
core