Results 111 to 120 of about 78,879 (253)

Correlation between hs-CRP-triglyceride glucose index and NAFLD and liver fibrosis

BMC Gastroenterology
Background The novel serum high-sensitivity C-reactive protein-triglyceride glucose index (CTI) has been recognized as an optimal parameter encompassing both insulin resistance (IR) and inflammation, which are potential mechanisms contributing to non ...
Yuhui Zhou, Hao Lin, Xiaochun Weng, Huifang Dai, Jing Xu   +4 more
doaj   +1 more source

Association between C-reactive protein-triglyceride glucose index and risk of sarcopenia in older adults: findings from CHARLS and NHANES

Experimental Gerontology
Background: Insulin resistance (IR) and inflammation are two crucial risk factors of sarcopenia. C-reactive protein-triglyceride glucose index (CTI) has been proposed to be a novel biomarker reflecting IR and inflammation.
Yan Chen, Tianchong Huang, Jiayin Wang, Changsheng Guo, Jing Gao, Xiaodong Feng   +5 more
doaj   +1 more source

Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study. [PDF]

, 2018
IntroductionUrinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury.
Bennett, Michael, Cushman, Mary, Dubin, Ruth F, Judd, Suzanne, Parikh, Chirag, Peralta, Carmen A, Powe, Neil, Sarnak, Mark, Scherzer, Rebecca, Shlipak, Michael, Warnock, David G   +10 more
core  

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]

, 2010
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
Adami, Adams, Adelman, Aguero-Torres, Ahima, Ahren, Akomolafe, Antuna-Puente, Arribas, Arvanitakis, Arvanitakis, Astrup, Bannon, Baran, Barber, Bartus, Barzilai, Baumbach, Baumbach, Baumbach, Behrendt, Bellinger, Berlett, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bjorntorp, Blander, Boden, Bolton, Bordone, Bordone, Brandes, Braun, Bravo, Broughton, Bruce-Keller, Buettner, Bugalho, Bullo, Cai, Calabrese, Calabrese, Calabrese, Calabrese, Calabrese, Carlsson, Carr, Cecarini, Cefalu, Cefalu, Chen, Chen, Chen, Clark, Clayton, Clayton, Comfort, Coon, Coyle, Coyle, Craft, Craft, Curb, Damjanovic, De Feo, de la Torre, Dechenes, DeFronzo, DeFronzo, DeKosky, Desai, Ding, Diniz, Droge, Dunn, d’Alessio, Eckles-Smith, Elahi, Elias, Elias, Elias, Fagot-Campagna, Fantuzzi, Farr, Fassbender, Ferrannini, Ferrannini, Ferrannini, Festa, Finch, Finkel, Franceschi, Freund, Fridlyand, Friedman, Frohman, Frolich, Fruhbeck, Fujimoto, Furukawa, Gabbita, Gabriely, Gazzaley, Gemma, Gibson, Gibson, Giunta, Gold, Gonzalez, Good, Granholm, Gray, Greenwood, Griffin, Gunning-Dixon, Gupta, Guttmann, Haan, Handschin, Harvey, Haslam, Heistad, Heitner, Ho, Hosokawa, Howard, Hoyer, Hsu, Hu, Hultsch, Hynd, Iqbal, Itateyama, Iyo, Izumi, James, Jankowsky, Janson, Jia, Joseph, Juhan-Vague, Kaasinen, Kanoski, Kennedy, Kirwan, Kissebah, Kitani, Klann, Klann, Knapp, Koenig, Kuk, Kumar, Kumari, Kuo, Kuriyama, Kuriyama, Laakso, Lamarche, Langan, Lau, Launer, Lee, Leibson, Leone, Lesser, Li, Lippa, Luchsinger, MacKnight, Magnusson, Maier, Manev, Mantena, Massaad, Matia, Matsuzawa-Nagata, Mattson, Mattson, Mattson, Mattson, McClearn, McNay, McNay, Medawar, Mendall, Meng, Messier, Michikawa, Miller, Miller, Milne, Moller, Moreira, Morin, Morrison, Muckle, Nag, Nagai, Navarro, Newton, Nielsen, Nisoli, Nunomura, Nyberg, Oakes, Ogawa, Oomura, Osmond, Ott, O’Shaughnessy, Pacini, Paolisso, Park, Partridge, Pasinetti, Pasinetti, Patterson, Pedigo, Peila, Peiris, Perlmuter, Perry, Perry, Petrovitch, Pfluger, Picard, Pinteaux, Pistell, Qiu, Qu, Rasouli, Razay, Rinne, Rizza, Rizza, Robertson-Tchabo, Roher, Roman, Rosamond, Rowe, Sattler, Sayre, Scacchi, Scheff, Schmitt-Schillig, Shen, Shi, Shimokata, Smith, Smith, Smith, Sohal, Sonntag, Souza, Spulber, Stadtman, Stadtman, Steemburgo, Steen, Strauss, Svedberg, Tanner, Tariot, Taylor, Terao, Terao, Terry, Tha, Thiels, Thiels, Tohgi, Tschop, Urakawa, Uz, van der Heide, van Exel, Vannucchi, Volkow, Wahrenberg, Wang, Wang, Wang, Ward, Wenk, White, Wieringa, Williams, Winocur, Wong, Woods, Wu, Wu, Xiao, Yaffe, Yasui, Ye, Yudkin, Zhang, Zhao, Zlokovic   +302 more
core   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality

Hepatology, EarlyView., 2022
Visualisation of the study desgin, main results and key findings. Abstract Background and Aims MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.
Laurens A. van Kleef, Robert J. de Knegt, Willem Pieter Brouwer   +2 more
wiley   +1 more source

Dual Layer Association of the C-Reactive Protein Triglyceride Glucose Index with Cardiovascular–Kidney–Metabolic Syndrome among Older Chinese Adults

Abstract Background: The cardiovascular–kidney–metabolic (CKM) syndrome reconceptualizes multimorbidity as a progressive, multisystem disorder. Yet, existing research focuses mainly on disease staging, neglecting the distinction between optimal health and any CKM risk burden. The C-reactive protein–triglyceride–glucose (CTI) index reflects both
JiaHao Shi, Anuchit Phanumartwiwath
openaire   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Link between C-reactive protein-triglyceride glucose index and cardiovascular disease risk in diverse glycemic statuses: insights from the CHARLS

Abstract Objective The C-reactive protein-triglyceride-glucose index (CTI) is a novel biomarker that integrates measures of insulin resistance and inflammation. Its association with cardiovascular disease (CVD) risk across various glycemic statuses remains unclear.
Shifeng Qiu, Chen Yu, Siyun Guo, Xuewei Liu, Qiuxia Zhang, Hao Zheng, Kai Cui, Yuegang Wang, Guojun Chen, Yanmei Chen, Qingchun Zeng, Xue Li, Juefei Wu, Jiancheng Xiu   +13 more
openaire   +1 more source