Results 151 to 160 of about 78,879 (253)

Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice

ChemMedChem, EarlyView.
A low‐toxicity bioactive composition of oxidovanadium(IV) and exopolysaccharide levan is synthesized, characterized, and shown to reduce hyperglycemia, hypertriglyceridemia, and TyG index in a mice model of dexamethasone‐induced insulin resistance. Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more ...
Amanda K. J. P. F. da Silva, Eucilene K. de L. B. Marques, Lidiane M. A. de Lima, Widarlane A. S. Alves, Dayane A. Gomes, Pedro L. Guzzo, Mônica F. Belian, Wagner E. Silva, Eduardo C. Lira   +8 more
wiley   +1 more source

C-reactive protein-triglyceride glucose index and fatty liver disease associated with metabolic dysfunction in U.S. adults: a cross-sectional study based on NHANES

Abstract Background C-reactive protein-triglyceride glucose index (CTI) has been identified as a novel inflammatory marker for comprehensive assessment of the severity of inflammation and insulin resistance, but the role of CTI in Metabolic dysfunction-associated steatotic liver disease(MASLD) is still unclear.
Sicheng Pu, Yan Li, Kezhen Zong, Tiantian Huang, Shanshan Li, Yuguan Zhang, Junliang Pu, Zongjun Wu, Hui Li, Zuotian Huang   +9 more
openaire   +1 more source

Increased plasma markers of oxidative stress are associated with coronary heart disease in males with diabetes mellitus and with 10-year risk in a prospective sample of males [PDF]

, 2006
Background: Increased oxidative stress is associated with coronary heart disease (CHD). We examined the association between plasma markers of oxidative stress and CHD in a cross-sectional sample of patients with diabetes and prospective CHD risk in a ...
Cooper, J.A., Gable, D.R., Humphries, S.E., Hurel, S.J., Miller, G.J., Stephens, J.W.   +5 more
core  

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Multivariate linear regression to predict association of non‐invasive arterial stiffness with cardiovascular events

ESC Heart Failure, Volume 12, Issue 2, Page 1141-1150, April 2025.
Abstract Background Arterial stiffness is a crucial factor in determining an increase in systolic blood pressure and pulse pressure and can also predict the development of cardiovascular disease (CVD). The purpose of this study was to examine the relationship between arterial stiffness and future CVD.
Susan Darroudi, Mostafa Eslamiyeh, Amin Mansoori, Eisa Nazar, Maryam Alinezhad‐Namaghi, Reza Rezvani, Majid Ghayour‐Mobarhan, Habibollah Esmaily, Mohsen Moohebati, Gordon A. Ferns, Mark Ghamsary   +10 more
wiley   +1 more source

Evaluating the visceral adiposity inflammatory index for enhanced stroke risk assessment

Scientific Reports
Stroke is a leading cause of global morbidity and mortality, with risk factors like visceral adiposity and inflammation playing significant roles. This study introduces the Visceral Adiposity Inflammatory Index (VAII), combining the Visceral Adiposity ...
Qun Xiao, Aohan Xue, Weicheng Huang, Jian Yuan   +3 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Proteome organ aging and cardiometabolic risk in a population at risk for heart failure

Cardiovascular Diabetology
Background Biological aging varies across individuals and tissues, influencing chronic diseases, including heart failure (HF). Emerging proteome techniques enable quantification of organ-specific aging acceleration (OAA), but whether OAA relates to HF ...
Kaiyong Qu, Elisa Dal Canto, Anne-Mar L. N. van Ommen, Sabrina Abou Kamar, Arco J. Teske, Maarten Jan Cramer, Marianne C. Verhaar, Dirk J. Duncker, Frans H. Rutten, Isabella Kardys, Roxana Menken, Leonard Hofstra, Igor I. Tulevski, G. Aernout Somsen, N. Charlotte Onland-Moret, Ernest Diez Benavente, Hester M. den Ruijter   +16 more
doaj   +1 more source

One‐Stone‐Three‐Birds Biomimetic Oral Targeting Delivery Strategy for On‐Demand Controlled Drug Release and Intervertebral Disc Degeneration Therapy

Exploration, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a multifactorial condition characterized by excessive inflammation, immune dysfunction, and metabolic disorders. Current therapeutic strategies primarily rely on local injection, a traumatic approach associated with risks of tissue damage and infection.
Yifan Ding, Yixin Cai, Weizhen Pan, Na Hu, Yunyun Wang, Huan Wang, Huang Fang, Songwei Tan, Zhiping Zhang   +8 more
wiley   +1 more source