Results 71 to 80 of about 78,879 (258)

Obese patients with a binge eating disorder have an unfavorable metabolic and inflammatory profile [PDF]

, 2015
To evaluate whether obese patients with a binge eating disorder (BED) have an altered metabolic and inflammatory profile related to their eating behaviors compared with non-BED obese.A total of 115 White obese patients consecutively recruited underwent ...
Aloi, M, Arturi, F, Caroleo, M, De Fazio, P, Rania, M, Ruffo, M, Segura-Garcia, C, Sesti, G, Succurro, E   +8 more
core   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

The Impact of Sodium-Glucose Co-Transporter-2 Inhibition on Insulin Resistance and Inflammation in Patients with Type 2 Diabetes: A Retrospective Study

Medicina
Background and Objectives: Insulin resistance (IR) is a key factor involved in the development of type 2 diabetes (T2D). Besides its role in the pathogenesis of T2D, insulin resistance is associated with impairment of glycemic control, reduced ...
Liana Iordan, Sandra Lazar, Romulus Timar, Simona Popescu, Teodora Sorescu, Oana Albai, Adina Braha, Bogdan Timar, Laura Gaita   +8 more
doaj   +1 more source

The association between blood glucose and oxidized lipoprotein(a) in healthy young women [PDF]

, 2010
Background Oxidized lipoproteins play important roles in the atherosclerotic processes. Oxidized lipoprotein(a) (oxLp(a)) may be more potent in atherosclerotic pathophysiology than native Lp(a), a cardiovascular disease-relevant lipoprotein.
Kazuhiko Kotani, Shingo Yamada, Shuumarjav Uurtuya, Toshiyuki Yamada, Nobuyuki Taniguchi, Ikunosuke Sakurabayashi, P Holvoet, SM Marcovina, S Erqou, S Yamada, TF Zioncheck, P Riis-Hansen, J Galle, JL Beaudeux, S Ren, N Komai, EA Podrez, J Wang, TJ Lyons, CJ Chang, K Shirai, HT Nguyen-Thanh, NG Chen, C Bergmark   +23 more
core   +2 more sources

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Economic insecurity during the Great Recession and metabolic, inflammatory and liver function biomarkers: analysis of the UK Household Longitudinal Study [PDF]

, 1993
Background: Economic insecurity correlates with adverse health outcomes, but the biological pathways involved are not well understood. We examine how changes in economic insecurity relate to metabolic, inflammatory and liver function biomarkers ...
Auston, Bennett, Chen, Doany, Foyt, Frankel, Frankel, Frankel, Gupta, Gupta, Hsiang, Jackson, Kaminska, Krökel, Lambsdorff, Lee, Lester, Nunnally, Nuss, Smith, Valdmanis, van Driel, van Zeghbroeck, Warren, Warren, Warren, Yablonovitch   +26 more
core   +4 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index [PDF]

Endocrinology and Metabolism, 2017
BackgroundPlasma soluble cluster determinant 36 (sCD36) level is closely related with insulin resistance and atherosclerosis, but little is known whether it could be a surrogate for estimating risk of developing diabetes or not.
Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee   +6 more
doaj   +1 more source

Associations between C-reactive protein-triglyceride glucose index and Endometriosis: the NHANES 1999-2006

Abstract Background: The C-reactive protein-triglyceride glucose index (CTI), a promising new marker, could evaluate the extent of inflammation. Endometriosis is a prevalent chronic inflammatory condition that is influenced by estrogen and primarily impacts individuals of reproductive age.
Yanan Ren, Ren Xu, Junqin Zhang, Ying Jin, Di Zhang, Yazhuo Wang, Luyang Su   +6 more
openaire   +1 more source

Extra virgin olive oil and cardiovascular diseases: benefits for human health [PDF]

, 2017
The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out ...
Cammisotto, Vittoria, Carnevale, Roberto, Castellani, Valentina, D'Amico, Alessandra, Fianchini, Luca, Nocella, Cristina, Novo, Marta, Stefanini, Lucia, Violi, Francesco   +8 more
core   +1 more source