Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Pathogen Evasion of Humoral Innate Immunity: Coping with C-Reactive Protein and Serum Amyloid A. [PDF]
Gong W, Cheng X, Villena J, Kitazawa H.
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Monomeric C-reactive protein as a therapeutic target in inflammatory diseases. [PDF]
Fujita C, Sakurai Y, Yasuda Y, Fujita M.
europepmc +1 more source
J, KWAPINSKI, B, RAU, K, BACZYNSKA
openaire +1 more source
The enigmatic role of the C-reactive protein and albumin in Behcet's disease. [PDF]
Jadali Z.
europepmc +1 more source
Machine Learning-Driven Prognostic Model Integrating Lymphocyte-to-C-Reactive Protein Ratio and TNM Staging in Gallbladder Cancer. [PDF]
Wang M, Chen Z, E F, Gu J, Bao R.
europepmc +1 more source
Stabilized C-reactive protein-albumin-lymphocyte (CALLY) index predicts adjacent fractures after kyphoplasty. [PDF]
Deng C +6 more
europepmc +1 more source
C-Reactive Protein in Saliva as a Non-Invasive Marker of Metabolic Syndrome: A Systematic Review and Meta-Analysis. [PDF]
Khalfan M +12 more
europepmc +1 more source

