Results 61 to 70 of about 1,696,441 (358)

Effect of atorvastatin on inflammation and outcome in patients with type 2 diabetes mellitus on hemodialysis [PDF]

, 2008
Statins have multiple effects, including anti-inflammatory actions, lowering C-reactive protein levels, and reducing coronary events. We performed a post hoc analysis of the randomized placebo-controlled 4D Study that had evaluated the efficacy and ...
Drechsler, Christiane, for the German Diabetes and Dialysis Study Investigators, , Krane, Vera, Lilienthal, Jürgen, März, Winfried, Wanner, Christoph, Winkler, Karl   +6 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Agar-Gel Precipitin-Inhibition Technique for C-Reactive Protein Determinations [PDF]

, 1965
John G. Ray, Donald E. Shay
  +5 more sources

The Correlation Between Level of C-Reactive Protein and Radiographic Grading of Knee Osteoarthritis [PDF]

, 2012
Introductions. Several studies have shown that the acute phase response may take place in osteoarthritis, suggesting that low grade systemic inflammation may be present in patients with osteoarthritis. Materials and methods. This study was aimed to
Bahar, B. (Burhanuddin), Saifullah, H. R. (H), Saleh, M. R. (M), Tata, H. (Harris), Yurianto, H. (Henry)   +4 more
core  

C-reactive protein: associations with haematological variables, cardiovascular risk factors and prevalent cardiovascular disease [PDF]

, 2003
C-reactive protein (CRP) has been proposed as a risk factor for cardiovascular disease; however, this association is confounded by mutual relationships with both classical and haematological cardiovascular risk factors. We, therefore, measured CRP with a
Ann Rumley, Crombie, Cushman, Danesh, Danesh, Danesh, Ford, Fröhlich, Gordon D. O. Lowe, Gussekloo, Hak, Hugh Tunstall-Pedoe, Hutchison, Imhof, Lagrand, Lowe, Lowe, Lowe, Lowe, Lowe, Mark Woodward, Mendall, Office of Population Censuses and Surveys, Ridker, Ridker, Smith, Vuilleumier, Woodward, Woodward, Woodward, World Health Organisation Principal Investigators, Yudkin   +31 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

An early warning tool for predicting mortality risk of COVID-19 patients using machine learning [PDF]

arXiv, 2020
COVID-19 pandemic has created an extreme pressure on the global healthcare services. Fast, reliable and early clinical assessment of the severity of the disease can help in allocating and prioritizing resources to reduce mortality. In order to study the important blood biomarkers for predicting disease mortality, a retrospective study was conducted on ...
arxiv  

In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]

ChemPhysChem 2020, 21, 377, 2019
We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
arxiv   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source