Results 41 to 50 of about 99,706,347 (248)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Annals of Gastroenterological Surgery, 2020 Aim Impact of several immune‐inflammatory markers on long‐term outcome has been reported in various malignancies. The aim of the present study was to evaluate through a meta‐analysis the oncological outcome of immune‐inflammatory markers, such as ...
Yusuke Ishibashi +4 more
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Association between Platelet-to-Lymphocyte Ratio, C-reactive Protein to Albumin Ratio, Red Cell Distribution Width, and APACHE II Score in Predicting Prognosis and Mortality in Sepsis [PDF]
Aim: Intensive care unit (ICU) provide critical care and treatment to enhance patient outcomes. There is limited data on new scoring systems that predict prognosis during sepsis.
Yeşim Şerife Bayraktar, Yasemin Cebeci
core +1 more source
, 2021 Objectives The clinical diagnosis of complicated acute cholecystitis (CAC) remains difficult with several pathological or ultrasonography criteria used to differentiate it from uncomplicated acute cholecystitis (UAC).
Thakkar, Mehual +4 more
core +1 more source
Journal of the Pakistan Medical AssociationObjective: To determine the correlation between inflammatory indices and the Tumour-Node-Metastasis stage of oesophageal carcinoma. Method: The prospective study was conducted from January 2021 to January 2023 at the Department of Upper ...
Sajida Qureshi +3 more
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Pteridines, 2015 The aim of the present study was to evaluate the correlations of peripheral blood cell count (PBC)-derived ratios with neopterin concentration and biomarkers of atherosclerosis risk in patients with history of breast cancer.
Študentová Hana +11 more
doaj +1 more source