Results 111 to 120 of about 44,074,051 (232)
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Calcium Silicate Hydrate (CSH) is a crucial material with diverse applications in construction, interior/exterior decoration, and high-tech industries due to its unique mechanical and physical properties.
Tran Ngo Quan, Pham Trung Kien
doaj +1 more source
International audienceHow cement-based materials behave in storage operating conditions is important in the context of a radwaste deep geological repository.
Vieillard, Philippe +19 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Spektroskopische Untersuchungen von C-S-H und dem C-S-H-Bindemittel Celitement
Das amorphe, Calciumsilikathydrat-basierte Bindemittel Celitement stellt eine umweltfreundlichere Alternative zu Portlandzement dar. Es wird durch die mechanochemische Aktivierung einer zuvor in einem Autoklav synthetisierten C-S-H-Phase hergestellt. Bei diesem Prozess bildet sich ein hydraulisches Calcium-Hydrosilikat.
openaire +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Calcium-alumina-silicate-hydrate (C-A-S-H) is the main hydration product formed in Portland composite cement pastes. C-A-S-H is a key phase with regard to the strength and durability of concrete.
Hemstad Petter +2 more
doaj +1 more source

