Results 121 to 130 of about 44,074,051 (232)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ecosistemas y Recursos Agropecuarios, 2016 Se utilizó el Sistema Integrado para Recomendar Dosis de Fertilización (SIRDF) para generar un programa de fertilización sustentable en plantaciones de cítricos de la Sabana de Huimanguilo, Tabasco, México.
Sergio Salgado-García +11 more
doaj
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Phosphate additive modification of C–S–H and C–A–S–H crystallization pathways
Phosphate-based additives are commonly used in concrete technology as hydration retarders and dispersion enhancers, playing a critical role in controlling cement hydration kinetics.
Ladner, Luca +4 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Envelope addressed to S. B. Simmons from C. H. Carroll
, 1930 Envelope addressed to S. B. Simmons from C. H. Carroll. R. W.
Carroll, C. H.
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
, 2010 Large-bite bisphosphite ligand 1,3-C(6)H(4){OPOC(10)H(6)(mu-S)C(10)H(6)O}(2) (3), is obtained by reacting chlorophosphonite {OC(10)H(6)(mu-S)C(10)H(6)O}PCl (2) with resorcinol in the presence of triethylamine.
KUMAR, P +7 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source